{"id":"W1965977355","doi":"10.1016/j.tetlet.2015.01.191","title":"Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro","year":2015,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; American Cancer Society; U.S. Department of Energy","keywords":"Chemistry; In vitro; Recombinant DNA; Liposome; Natural product; Family member; Cell biology; Biophysics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001089982,0.0003370158,0.0005387623,0.0003034952,0.00007035785,0.00001422323,0.0005623031,0.0003500814,0.0002248625],"category_scores_gemma":[0.000276613,0.0003141317,0.0001323563,0.0006479599,0.0003286792,0.0002443629,0.0001395638,0.001403714,0.0001175467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004320873,"about_ca_system_score_gemma":0.00009430186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006225803,"about_ca_topic_score_gemma":0.000005969046,"domain_scores_codex":[0.9971476,0.0007618227,0.0005445741,0.0004619297,0.000363407,0.0007206869],"domain_scores_gemma":[0.9985139,0.0006147692,0.0002109963,0.0001977152,0.0001008111,0.0003617626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002433951,0.0005142981,0.008641498,0.00003869581,0.0001106378,0.0001409799,0.0003301898,0.001101847,0.9735543,0.00003789701,0.009652705,0.003442959],"study_design_scores_gemma":[0.008789878,0.0004186259,0.01929597,0.00001828577,0.00009793374,0.00003142132,0.00008100046,0.003316846,0.9570501,0.0005284378,0.009833609,0.0005378561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927353,0.0004963731,0.0000550138,0.003172796,0.001245468,0.0005933287,0.00003970618,0.0001334425,0.001528553],"genre_scores_gemma":[0.9899523,0.00002160274,0.0005982124,0.009030699,0.0001853553,0.00004804348,0.00003605908,0.0000306096,0.00009716412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01650421,"threshold_uncertainty_score":0.9999311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1413404721579011,"score_gpt":0.4322807855110253,"score_spread":0.2909403133531241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}