{"id":"W1966003468","doi":"10.1038/mt.2012.155","title":"Targeting TCTP as a New Therapeutic Strategy in Castration-resistant Prostate Cancer","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Ligue Contre le Cancer","keywords":"Gene knockdown; Hsp27; Prostate cancer; Cancer research; Cytoprotection; Androgen deprivation therapy; Heat shock protein; Biology; Medicine; Cancer; Hsp70; Internal medicine; Cell culture; Apoptosis; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234268,0.000228671,0.000301278,0.0001164288,0.00005985695,0.00004109175,0.00009065994,0.0000951669,0.0004066733],"category_scores_gemma":[0.00002567868,0.0001943797,0.0001103456,0.0002604053,0.00005110039,0.0001252884,0.000008564269,0.0002076142,0.00003850768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287515,"about_ca_system_score_gemma":0.000678878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002139739,"about_ca_topic_score_gemma":0.00005270436,"domain_scores_codex":[0.9985423,0.0001283915,0.0003036378,0.0002350219,0.0002819233,0.0005087027],"domain_scores_gemma":[0.9993311,0.00003049841,0.00009180018,0.000276224,0.00005243624,0.00021791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003660974,0.0002718146,0.008030778,0.0000380175,0.0001414996,0.0001407976,0.002431127,0.0002287549,0.8987955,0.0002563976,0.0005108662,0.08549343],"study_design_scores_gemma":[0.01753368,0.002475792,0.1795082,0.0006154422,0.0001868368,0.0003374653,0.002812693,0.000377797,0.4488315,0.0007747669,0.3450944,0.001451445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9117615,0.0847953,0.00006774286,0.001829659,0.0001248234,0.0006634421,0.000002917326,0.0000467013,0.0007079078],"genre_scores_gemma":[0.9904644,0.004749089,0.00009504172,0.002153052,0.0003089996,0.00009385559,0.00001947824,0.00005676831,0.002059279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.449964,"threshold_uncertainty_score":0.7926576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264307145074476,"score_gpt":0.3105803946805021,"score_spread":0.2879373232297574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}