{"id":"W1966039777","doi":"10.2174/156802607780487795","title":"Nucleobase Modifications in Peptide Nucleic Acids","year":2007,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleic acid; Nucleobase; Peptide nucleic acid; Oligonucleotide; DNA; Nucleic acid analogue; Chemistry; RNA; Combinatorial chemistry; Polyamide; Peptide; Glycine; Nucleic acid methods; Biochemistry; Amino acid; Nucleic acid thermodynamics; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108256,0.0007100402,0.0005976622,0.0007333251,0.0001779468,0.000343266,0.0004528372,0.0006251882,0.001326485],"category_scores_gemma":[0.0001716458,0.0002705875,0.0001707124,0.0008884155,0.0002991468,0.0005037769,0.0003589111,0.0006874091,0.002242656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003385225,"about_ca_system_score_gemma":0.0002395749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003318489,"about_ca_topic_score_gemma":0.0005006018,"domain_scores_codex":[0.9998772,0.00001809748,0.000009850247,0.00002998381,0.00005192649,0.00001282951],"domain_scores_gemma":[0.999958,0.00001472308,0.000009273316,0.000002887572,0.000009735764,0.00000529233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008554042,0.0001163173,0.0001511634,0.00933491,0.00005005762,0.000797345,0.0001433172,0.0009765288,0.2189527,0.008638482,0.007280299,0.7534734],"study_design_scores_gemma":[0.00002163114,0.00026002,0.0006367682,0.0006233586,0.00004037014,0.003472531,0.0000348384,0.0002263257,0.09190238,0.001761758,0.9009942,0.00002576389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004266998,0.9847088,0.002497906,0.0001518404,0.0003436984,0.0000263054,0.00003291297,0.00005154967,0.007919985],"genre_scores_gemma":[0.01952802,0.9689806,0.003502871,0.0002548307,0.0002022128,0.00004248927,0.00008344676,0.000009509633,0.00739612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001326485,"threshold_uncertainty_score":0.004437506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05642702863086606,"score_gpt":0.3709538644284818,"score_spread":0.3145268357976158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}