{"id":"W1966039827","doi":"10.6000/1929-2279.2014.03.02.5","title":"The Overexpression of ABCG2 Reduces the Efficacy of Volasertib (BI 6727) and GSK641364 in Human S1-M1-80 Colon Carcinoma Cells","year":2014,"lang":"en","type":"article","venue":"Journal of cancer research updates","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PLK1; Abcg2; Cell cycle checkpoint; Cell cycle; Cancer research; Cell growth; Cancer cell; Biology; Kinase; Cancer; Cell; Chemistry; Transporter; Cell biology; ATP-binding cassette transporter; Biochemistry; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002475055,0.0001155974,0.0004022996,0.000203485,0.0001923429,0.00002764394,0.0003557853,0.00007714199,0.00005640914],"category_scores_gemma":[0.0001729259,0.00005555475,0.0001084045,0.0002833738,0.0004742322,0.00009034269,0.00005351471,0.00062278,8.12698e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006604077,"about_ca_system_score_gemma":0.0002616128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002732408,"about_ca_topic_score_gemma":0.0002621267,"domain_scores_codex":[0.9976637,0.0002579683,0.0006245803,0.0001410664,0.0009879477,0.0003247122],"domain_scores_gemma":[0.998156,0.0005799751,0.0003605281,0.0002690074,0.0005022241,0.0001322315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002032931,0.00030616,0.009992216,0.0001982385,0.00005998513,0.00001547866,0.0008572963,0.00002252564,0.9800718,0.0003961713,0.002446425,0.003600749],"study_design_scores_gemma":[0.004076605,0.000783198,0.05428809,0.001291119,0.00004626582,0.000007363602,0.0008284886,0.00005369032,0.9314353,0.0009246779,0.006201594,0.00006353022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922029,0.004212193,0.000004375041,0.002713977,0.0001178306,0.0002942205,0.00000822153,0.000002374834,0.0004439531],"genre_scores_gemma":[0.9976056,0.001661578,0.0000617648,0.00002832357,0.0002095639,0.000007246467,0.000002013209,0.00001656546,0.0004073712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04863645,"threshold_uncertainty_score":0.2705704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02839890587300924,"score_gpt":0.3678702082740271,"score_spread":0.3394713024010179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}