{"id":"W1966049097","doi":"10.1016/j.jsb.2008.01.006","title":"Conformational changes accompany activation of reovirus RNA-dependent RNA transcription","year":2008,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Capsid; RNA; Nucleic acid; Messenger RNA; Biophysics; Transcription (linguistics); Core protein; Conformational change; Polymerase; Chemistry; RNA polymerase; Icosahedral symmetry; Biology; Cell biology; Biochemistry; Enzyme; Crystallography; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609484,0.00009977532,0.0004523681,0.0002283611,0.00005405664,0.000002585154,0.0001078058,0.0001130338,0.0002469296],"category_scores_gemma":[0.0002231487,0.00006815256,0.0001239247,0.00007151711,0.0002013656,0.0001655415,0.00001690421,0.0003149139,0.000003990695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007213932,"about_ca_system_score_gemma":0.00008569808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004450931,"about_ca_topic_score_gemma":0.000006926644,"domain_scores_codex":[0.998803,0.0001219268,0.0005704112,0.00008300434,0.0001943051,0.0002273521],"domain_scores_gemma":[0.9989715,0.0000338115,0.0004536645,0.00007762889,0.0003425822,0.0001208522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001780578,0.00001997281,0.02060839,0.00003913733,0.0001170861,0.00002368756,0.0001847378,0.00001958342,0.9614,0.0001900768,0.000677547,0.01493918],"study_design_scores_gemma":[0.004782446,0.005208535,0.852641,0.000127049,0.0000481454,0.006461436,0.0002497243,0.0002264392,0.1268748,0.001054701,0.002197127,0.0001285439],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955376,0.00023212,0.0004340588,0.003196081,0.0002802086,0.0001056526,0.00002534233,0.000005683582,0.0001832416],"genre_scores_gemma":[0.9975517,0.0005612566,0.001031282,0.0004010954,0.0003605313,0.000001375975,0.00004195005,0.00000494666,0.00004582741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8345252,"threshold_uncertainty_score":0.2779181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05736275598491658,"score_gpt":0.3333493753611599,"score_spread":0.2759866193762434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}