{"id":"W1966081925","doi":"10.1074/jbc.m805878200","title":"Caspase 8 Promotes Peripheral Localization and Activation of Rab5","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency","funders":"National Institutes of Health; National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro","keywords":"Endosome; Rab; Cell biology; Signal transducing adaptor protein; Proto-oncogene tyrosine-protein kinase Src; Small GTPase; Phosphorylation; SH3 domain; GTPase; Kinase; Pleckstrin homology domain; Biology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009653436,0.00007128608,0.0001267978,0.00000955248,0.00003299268,0.000002817387,0.00005416737,0.0001560866,0.00003647301],"category_scores_gemma":[0.00007032177,0.00005259359,0.00006752914,0.00003693466,0.00009546705,0.000004158404,0.00001268321,0.00007226641,8.803843e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006813117,"about_ca_system_score_gemma":0.00003242784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001785451,"about_ca_topic_score_gemma":2.031996e-7,"domain_scores_codex":[0.9995131,0.00001605108,0.0002326391,0.00009154981,0.00007745786,0.00006916936],"domain_scores_gemma":[0.9995872,0.00000622064,0.0001805868,0.00006050899,0.0001157055,0.00004974124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001554756,0.00005375026,0.02216982,0.00002330531,0.00001696999,0.00000762631,0.00003301118,0.00002896056,0.9772691,0.000002001601,0.00002328695,0.0002167084],"study_design_scores_gemma":[0.0003856049,0.0002528073,0.007096554,0.00001645705,0.000007702783,0.0002016214,0.00004004263,0.00006030125,0.9901469,0.00003460482,0.001689673,0.00006770196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853082,0.0004249941,0.01405137,0.00004070237,0.00001780557,0.00003099596,0.000002545948,0.000001945798,0.00012145],"genre_scores_gemma":[0.9987693,0.0005621449,0.0002732711,0.00002610823,0.0001447046,6.014837e-7,0.0001687651,0.000003888904,0.00005118535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01507326,"threshold_uncertainty_score":0.2144704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172531297053359,"score_gpt":0.224585599412305,"score_spread":0.2073324697069691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}