{"id":"W1966081925","doi":"10.1074/jbc.m805878200","title":"Caspase 8 Promotes Peripheral Localization and Activation of Rab5","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency","funders":"National Institutes of Health; National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro","keywords":"Endosome; Rab; Cell biology; Signal transducing adaptor protein; Proto-oncogene tyrosine-protein kinase Src; Small GTPase; Phosphorylation; SH3 domain; GTPase; Kinase; Pleckstrin homology domain; Biology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412814,0.0002756812,0.0001515451,0.0001782893,0.0001668382,0.0003523842,0.0001569201,0.000180818,0.003338414],"category_scores_gemma":[0.0001848133,0.00009217996,0.0001759615,0.00008162885,0.0001474505,0.0002286287,0.0003250736,0.0004568225,0.0009947228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004578568,"about_ca_system_score_gemma":0.0001801181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000255284,"about_ca_topic_score_gemma":0.000338793,"domain_scores_codex":[0.9998478,0.00002216623,0.000008764108,0.00003071187,0.0000361142,0.00005434253],"domain_scores_gemma":[0.9998827,0.00001516364,0.00002648025,0.00001535242,0.00002848339,0.00003177255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437945,0.00003038593,0.000174961,0.00003330908,0.00000267726,0.00005601121,0.00001469785,0.0000506486,0.9970312,0.0003810324,0.00009729053,0.001983925],"study_design_scores_gemma":[0.00003983884,0.0002144747,0.003239401,0.000009147714,0.000008157012,0.0003609661,0.00002931716,0.001454454,0.9904485,0.0002147641,0.003978118,0.000002910001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919363,0.001445605,0.002758111,0.0001452693,0.00002461939,0.00001462906,0.0001051072,0.000100765,0.00346953],"genre_scores_gemma":[0.9953524,0.0003744632,0.001000701,0.00002776542,0.000008478885,0.000008849042,0.0001738859,0.000009838849,0.003043688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003338414,"threshold_uncertainty_score":0.01116812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172531297053359,"score_gpt":0.224585599412305,"score_spread":0.2073324697069691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}