{"id":"W1966123031","doi":"10.1002/pmic.200500230","title":"A modified tandem affinity purification strategy identifies cofactors of the <b><i>Drosophila</i></b> nuclear receptor dHNF4","year":2006,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Tandem affinity purification; Cofactor; Biology; Biochemistry; Function (biology); Nuclear receptor; FLAG-tag; DNA-binding protein; Nuclear protein; Gene; Cell biology; Affinity chromatography; Recombinant DNA; Transcription factor; Fusion protein; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003255069,0.0001451926,0.0001455251,0.00003696749,0.0001599582,0.00004985391,0.0004372221,0.0002191284,0.00003260492],"category_scores_gemma":[0.0001698581,0.0001177969,0.0001125256,0.000162225,0.0001914219,0.000008251995,0.0001751125,0.0001909094,0.00001849717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003675219,"about_ca_system_score_gemma":0.0001571558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001868317,"about_ca_topic_score_gemma":0.00005358932,"domain_scores_codex":[0.9987024,0.0001439347,0.000310995,0.0003080438,0.0002741481,0.0002604452],"domain_scores_gemma":[0.9990388,0.00001019777,0.000142328,0.0005873456,0.0001700679,0.00005124316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006089667,0.0000837816,0.001080071,0.00003106396,0.0000153561,2.290003e-7,0.00002222658,0.000328443,0.9965512,0.0008045567,0.0008119443,0.0002102333],"study_design_scores_gemma":[0.0003124146,0.00009620547,0.006070909,0.00001285865,0.00000614933,0.000002377745,0.00003320463,0.0001464616,0.9896978,0.001000154,0.002483911,0.0001376039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963035,0.0001098174,0.0003815658,0.0003168454,0.00008317034,0.000918426,0.00004953684,0.0000183515,0.001818798],"genre_scores_gemma":[0.998133,0.00005768202,0.0007473509,0.00002622964,0.0001750798,0.00007446117,0.00005233283,0.00003313647,0.0007006983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006853447,"threshold_uncertainty_score":0.4803617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854965572003144,"score_gpt":0.2546256374990014,"score_spread":0.23607598177897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}