{"id":"W1966132554","doi":"10.1021/ol502777r","title":"Dual-Face Nucleoside Scaffold Featuring a Stereogenic All-Carbon Quaternary Center. Intramolecular Silicon Tethered Group-Transfer Reaction","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Terry Fox Research Institute; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Stereocenter; Intramolecular force; Nucleoside; Quaternary carbon; Molecule; Combinatorial chemistry; Stereochemistry; Carbon atom; Scaffold; Atom (system on chip); Ring (chemistry); Catalysis; Organic chemistry; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007650894,0.0003954482,0.0001966362,0.0001827044,0.0001521702,0.0002666255,0.0003175139,0.000372108,0.001073175],"category_scores_gemma":[0.00009701571,0.0001521482,0.000168729,0.0001962006,0.0002023813,0.0002592742,0.0002775452,0.0004548303,0.0005874195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002777528,"about_ca_system_score_gemma":0.0002792722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002893989,"about_ca_topic_score_gemma":0.0005657781,"domain_scores_codex":[0.9999306,0.0000087776,0.000003955997,0.00002002426,0.0000183366,0.00001825129],"domain_scores_gemma":[0.9999491,0.000006525207,0.00001593047,0.000006289633,0.000007139688,0.0000149076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008937527,0.00002634302,0.0001097892,0.00006947766,0.000007931916,0.0001487473,0.00001974763,0.0007652583,0.9897963,0.001471523,0.0001393684,0.00735625],"study_design_scores_gemma":[0.00001732347,0.0003034214,0.0003099581,0.000003765922,0.0000134533,0.0003182747,0.000007676958,0.001162319,0.9916726,0.0001716944,0.006007517,0.00001185516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9306021,0.002313517,0.04649978,0.0002201998,0.0001442367,0.0001110247,0.0005769244,0.0005353513,0.01899688],"genre_scores_gemma":[0.969675,0.0008082158,0.02542255,0.00007274507,0.00001786693,0.00004406341,0.000372086,0.00003442971,0.003553058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073175,"threshold_uncertainty_score":0.003590167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005240963484102099,"score_gpt":0.1974369063258641,"score_spread":0.192195942841762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}