{"id":"W1966157768","doi":"10.1038/labinvest.2010.2","title":"3D Telomere FISH defines LMP1-expressing Reed–Sternberg cells as end-stage cells with telomere-poor ‘ghost' nuclei and very short telomeres","year":2010,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; University of Manitoba","keywords":"Telomere; Telomerase; Biology; In situ hybridization; Cell division; Cancer cell; Molecular biology; Cancer research; Cell; DNA; Cancer; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002826702,0.0002322453,0.0002259651,0.0005540372,0.0002151102,0.0003014441,0.000227096,0.0004366194,0.002425595],"category_scores_gemma":[0.0002235587,0.0002758311,0.0001741349,0.0002438979,0.0004294423,0.000340522,0.0003730691,0.0004542527,0.0009600743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373387,"about_ca_system_score_gemma":0.0001251718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005609935,"about_ca_topic_score_gemma":0.0008580381,"domain_scores_codex":[0.999864,0.00001980936,0.00001596727,0.00002904452,0.00002952487,0.00004162578],"domain_scores_gemma":[0.9997732,0.00006224983,0.00005288347,0.00004326258,0.00001520342,0.0000531697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000209975,0.00001541737,0.001584669,0.00002720264,0.000006000882,0.0003020525,0.0001212406,0.0001263423,0.9950943,0.0005991096,0.000072198,0.001841508],"study_design_scores_gemma":[0.00005352411,0.0002574219,0.03409047,0.00001154129,0.00002215796,0.00408911,0.0001927029,0.002786674,0.9531556,0.0005200832,0.00480335,0.00001731331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907421,0.0004412463,0.005643834,0.0000783447,0.000009179067,0.00002598097,0.000335215,0.0001697304,0.002554323],"genre_scores_gemma":[0.9853652,0.0002205399,0.01035018,0.00004454665,0.000009106902,0.00004465954,0.0005941311,0.00007413536,0.003297451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002425595,"threshold_uncertainty_score":0.008114398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112002680368054,"score_gpt":0.2312676325539631,"score_spread":0.2200673645171577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}