{"id":"W1966157768","doi":"10.1038/labinvest.2010.2","title":"3D Telomere FISH defines LMP1-expressing Reed–Sternberg cells as end-stage cells with telomere-poor ‘ghost' nuclei and very short telomeres","year":2010,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; University of Manitoba","keywords":"Telomere; Telomerase; Biology; In situ hybridization; Cell division; Cancer cell; Molecular biology; Cancer research; Cell; DNA; Cancer; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004876856,0.0007617779,0.0008297033,0.000459089,0.0004830651,0.0003027935,0.0003205024,0.0005369017,0.0004559229],"category_scores_gemma":[0.0002495897,0.0006711232,0.00009423072,0.001082565,0.001144617,0.001011319,0.000132374,0.001112308,0.0001484547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009597116,"about_ca_system_score_gemma":0.0007324257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003366939,"about_ca_topic_score_gemma":0.0005432265,"domain_scores_codex":[0.9960724,0.0001655171,0.000819568,0.001152146,0.0009610681,0.0008292973],"domain_scores_gemma":[0.9968953,0.0002415614,0.0003621224,0.001012287,0.0005801616,0.0009085288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002432076,0.0001402023,0.09105564,0.0004792676,0.0001045907,0.0002584661,0.001233248,0.00001385163,0.8984305,0.0003925057,0.00304786,0.004600682],"study_design_scores_gemma":[0.001640849,0.0004861364,0.05834837,0.0005830969,0.0002751863,0.0001204612,0.001013465,0.0002753638,0.8916758,0.0001071117,0.04443009,0.001044076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945442,0.0003170883,0.00002016534,0.0008541024,0.0008399368,0.0008556213,0.0002681924,0.0004229508,0.001877744],"genre_scores_gemma":[0.9846196,0.0001913043,0.008325635,0.004468872,0.000669863,0.00007498081,0.0001713913,0.0001871097,0.001291216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04138223,"threshold_uncertainty_score":0.999574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112002680368054,"score_gpt":0.2312676325539631,"score_spread":0.2200673645171577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}