{"id":"W1966181020","doi":"10.1016/s0006-3223(99)00301-7","title":"Molecular genetics of Alzheimer’s disease","year":2000,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":270,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Genetics; Biology; Presenilin; Alzheimer's disease; Apolipoprotein E; Missense mutation; Chromosome 21; Allele; Disease; Proband; Gene; Family aggregation; Molecular genetics; Chromosome; Mutation; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004602488,0.0001354769,0.0002183786,0.00003559912,0.00003553396,0.00000435435,0.00008517165,0.00008363179,0.001957364],"category_scores_gemma":[0.00001426493,0.00008927697,0.0002027652,0.0001222946,0.0001631245,0.00001431646,0.00002232873,0.0001033309,0.0002613681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008315645,"about_ca_system_score_gemma":0.0001670971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006637458,"about_ca_topic_score_gemma":2.489064e-7,"domain_scores_codex":[0.9990056,0.00005182627,0.0002058723,0.0002594824,0.0002133066,0.0002639428],"domain_scores_gemma":[0.9990682,0.000012357,0.00003243155,0.0003212744,0.00003945451,0.0005263006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002145428,0.003269538,0.9627914,0.00004459645,0.0045433,0.0002556338,0.000008222159,0.00001214892,0.0003967808,0.001657885,0.002242661,0.02263234],"study_design_scores_gemma":[0.001642174,0.0009009356,0.9905658,0.00004751593,0.0006493766,0.00001092583,0.00001184734,0.00005260374,0.0004011747,0.004245421,0.001318581,0.0001535985],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9203084,0.07326213,0.00000548319,0.0009961507,0.00006227707,0.0003294054,0.00005214737,0.00004468085,0.004939346],"genre_scores_gemma":[0.9972044,0.0009966411,0.001035172,0.0005372225,0.00009588324,0.00001953999,0.00008127039,0.00001143015,0.00001841538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07689604,"threshold_uncertainty_score":0.998955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04531564252233334,"score_gpt":0.3361727815924262,"score_spread":0.2908571390700929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}