{"id":"W1966193246","doi":"10.1016/j.bmcl.2013.08.020","title":"Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Peptidomimetic; Amide; Stereochemistry; Azide; Peptide; Biological activity; Peptide synthesis; Enkephalin; Hydrogen bond; Triazole; δ-opioid receptor; Solid-phase synthesis; Combinatorial chemistry; Cycloaddition; Carboxamide; Alkyne; Opioid; Receptor; Catalysis; In vitro; Organic chemistry; Biochemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581523,0.0003175309,0.0003572684,0.0002000837,0.000169876,0.0002648957,0.0005429819,0.000340802,0.001116314],"category_scores_gemma":[0.0004478263,0.0002065788,0.0002610225,0.0003377263,0.0002587072,0.0002233143,0.0001708184,0.000509507,0.0004453727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003292399,"about_ca_system_score_gemma":0.0004780949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013644,"about_ca_topic_score_gemma":0.002108017,"domain_scores_codex":[0.9998036,0.00005031159,0.00003342999,0.00002689608,0.00003745153,0.00004840495],"domain_scores_gemma":[0.9997997,0.00003366456,0.00007730399,0.0000290933,0.00002622109,0.00003396401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007639343,0.00008171188,0.0002976679,0.00005214102,0.0000211866,0.0002771172,0.00004730587,0.0008045718,0.9931319,0.000264972,0.00006316078,0.004194244],"study_design_scores_gemma":[0.0001432719,0.001108448,0.001657208,0.00001184668,0.00007015067,0.0005231506,0.00004456595,0.001435126,0.9928645,0.00006092896,0.002060269,0.00002061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972283,0.0005022624,0.001130157,0.00005695234,0.00003487724,0.00003959613,0.0001701821,0.00004266879,0.0007950584],"genre_scores_gemma":[0.9969971,0.0004559966,0.001609809,0.00003713491,0.00001213957,0.0000175191,0.0001429664,0.00002830255,0.0006989471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116314,"threshold_uncertainty_score":0.00373441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005106642376764243,"score_gpt":0.2156484878116275,"score_spread":0.2105418454348633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}