{"id":"W1966193246","doi":"10.1016/j.bmcl.2013.08.020","title":"Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Peptidomimetic; Amide; Stereochemistry; Azide; Peptide; Biological activity; Peptide synthesis; Enkephalin; Hydrogen bond; Triazole; δ-opioid receptor; Solid-phase synthesis; Combinatorial chemistry; Cycloaddition; Carboxamide; Alkyne; Opioid; Receptor; Catalysis; In vitro; Organic chemistry; Biochemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005968076,0.0002359162,0.0004141118,0.00001595857,0.00006454737,0.00002969865,0.0003165193,0.0001101371,0.0001764894],"category_scores_gemma":[0.0005598131,0.000115445,0.0001523231,0.0001378855,0.0003916723,0.000005712123,0.00008439561,0.0001704209,0.000004610489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005602816,"about_ca_system_score_gemma":0.00003396026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004675119,"about_ca_topic_score_gemma":0.00000362748,"domain_scores_codex":[0.9986581,0.0001310702,0.000388893,0.0003283981,0.0002593936,0.0002341554],"domain_scores_gemma":[0.9989187,0.000242811,0.0002459004,0.0004735289,0.00003584165,0.00008318598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643869,0.00005254157,0.0005755026,0.0004495672,0.0001750399,5.014005e-7,0.00004480722,0.00000213869,0.9921629,0.000002446163,0.006287319,0.00008280492],"study_design_scores_gemma":[0.0007613193,0.00002970292,0.0004080838,0.0005004535,0.00007846097,0.000006502564,0.000234125,0.00009765732,0.997662,0.000008718124,0.0000734725,0.0001395087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928128,0.001221503,0.00005433883,0.005452565,0.00002093593,0.0003558032,0.00001986258,0.000005701397,0.00005647922],"genre_scores_gemma":[0.9988829,0.0002859061,0.000009384675,0.0005410471,0.0001177515,0.00006807349,0.00003385155,0.00001446693,0.0000465798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006213846,"threshold_uncertainty_score":0.470771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005106642376764243,"score_gpt":0.2156484878116275,"score_spread":0.2105418454348633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}