{"id":"W1966236756","doi":"10.1016/j.nano.2014.05.010","title":"Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: Towards non-invasive glaucoma gene therapy","year":2014,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network; University of Toronto; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Biodistribution; Glaucoma; Medicine; Genetic enhancement; Pharmacology; Ophthalmology; Gene; Biology; In vivo; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003938118,0.0002177373,0.000427263,0.00009688663,0.00007702754,0.000003194246,0.0001117711,0.0006131539,0.00001449554],"category_scores_gemma":[0.0003127505,0.0001564322,0.00002626922,0.00007978328,0.001601261,0.000005538332,0.0001181878,0.0001549278,9.194746e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007249001,"about_ca_system_score_gemma":0.0000956869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001612671,"about_ca_topic_score_gemma":0.00003490535,"domain_scores_codex":[0.9986609,0.00007202494,0.0004595933,0.0004819059,0.00007598956,0.000249537],"domain_scores_gemma":[0.9993537,0.00006470219,0.0001315259,0.0002391064,0.00009451828,0.000116438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005812811,0.00006040642,0.06113749,0.00003358539,0.00008790761,0.000008405964,0.0001295697,1.156945e-8,0.8174239,0.0002412356,0.00008115226,0.1202151],"study_design_scores_gemma":[0.002481944,0.006281525,0.1164473,0.00007766645,0.00004831486,0.0001737277,0.0001279377,0.000008457026,0.8637791,0.0004612809,0.009936179,0.0001766387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893506,0.005963568,0.0008879273,0.003394969,0.0001445686,0.0002010383,0.00001084939,0.00001519184,0.0000313075],"genre_scores_gemma":[0.9935234,0.00472205,0.000640535,0.0006665375,0.0002274685,0.00004101272,0.0001392627,0.000007698955,0.00003208908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1200384,"threshold_uncertainty_score":0.6379122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229093565781214,"score_gpt":0.282559048314143,"score_spread":0.2702681126563309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}