{"id":"W1966236756","doi":"10.1016/j.nano.2014.05.010","title":"Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: Towards non-invasive glaucoma gene therapy","year":2014,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network; University of Toronto; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Biodistribution; Glaucoma; Medicine; Genetic enhancement; Pharmacology; Ophthalmology; Gene; Biology; In vivo; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006573942,0.0002874937,0.0001483019,0.0002145074,0.0001822498,0.0002482661,0.0002279131,0.0003703384,0.0008251329],"category_scores_gemma":[0.0003080507,0.0001985557,0.0002190735,0.000126324,0.0003365733,0.0003871942,0.0001532591,0.0004927983,0.0002102079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004420046,"about_ca_system_score_gemma":0.0005130911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928112,"about_ca_topic_score_gemma":0.001910332,"domain_scores_codex":[0.9998497,0.00003323191,0.00001061238,0.00003185062,0.00003698389,0.00003760752],"domain_scores_gemma":[0.9998521,0.00003390362,0.00004356705,0.00001826875,0.00002447769,0.00002772633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004085175,0.0001746337,0.0002473234,0.00005922107,0.000006674868,0.00003879985,0.00006560147,0.0002315801,0.9945531,0.0001576386,0.00005978017,0.003997034],"study_design_scores_gemma":[0.00003635288,0.002254665,0.0009446961,0.000004272432,0.00003172566,0.00008754568,0.00001977414,0.0007659215,0.994202,0.0000353729,0.001612883,0.000004818025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858294,0.001948833,0.009949199,0.0001232483,0.00004448857,0.000242064,0.0001546782,0.00008575396,0.001622225],"genre_scores_gemma":[0.9898105,0.001219447,0.005933713,0.00004642639,0.00001312671,0.0001432099,0.0001951234,0.0000281114,0.002610338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928112,"threshold_uncertainty_score":0.003833711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229093565781214,"score_gpt":0.282559048314143,"score_spread":0.2702681126563309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}