{"id":"W1966280771","doi":"10.1016/j.canlet.2011.11.028","title":"Developmental pathways in breast cancer and breast tumor-initiating cells: Therapeutic implications","year":2011,"lang":"en","type":"review","venue":"Cancer Letters","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Wnt signaling pathway; Stem cell; Cancer research; Breast cancer; Biology; Metastasis; Hedgehog; Angiogenesis; Cancer stem cell; Cancer; Embryonic stem cell; Tumor initiation; Bioinformatics; Medicine; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001187486,0.00043044,0.0006391397,0.00009959438,0.0001169667,0.00002894513,0.0002630388,0.0001575898,0.0000294542],"category_scores_gemma":[0.000004276062,0.0003901632,0.000141901,0.0001656293,0.000143133,0.000005253426,0.0001728522,0.0002378127,0.000009697503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887172,"about_ca_system_score_gemma":0.0004477678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001642434,"about_ca_topic_score_gemma":0.0001259971,"domain_scores_codex":[0.9983824,0.00008100541,0.0004179614,0.0006379142,0.00007500131,0.0004057219],"domain_scores_gemma":[0.9994128,0.00002272934,0.0002324408,0.0002039624,0.000043595,0.00008452001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001100499,0.00003661434,0.001679259,0.002675149,0.0004385957,0.00001201389,0.0003216167,0.000002613427,0.03252343,0.00001572943,0.001372115,0.9609119],"study_design_scores_gemma":[0.0004911029,0.00002160888,0.004269273,0.005951296,0.0004175741,0.0003873402,0.0001083928,0.000001236324,0.0009833494,0.000007512492,0.98607,0.00129126],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004641992,0.9932817,0.00003074224,0.0002337326,0.0001817113,0.0004332798,0.001044995,0.00001887985,0.000132979],"genre_scores_gemma":[0.004418724,0.9922467,0.0001159373,0.001729787,0.0003588213,0.0009390801,0.00008745511,0.00008302162,0.0000204995],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9846979,"threshold_uncertainty_score":0.999855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05981011850684272,"score_gpt":0.3005722580519004,"score_spread":0.2407621395450577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}