{"id":"W1966286622","doi":"10.1021/bi901400p","title":"Directed “<i>in Situ</i>” Inhibitor Elongation as a Strategy To Structurally Characterize the Covalent Glycosyl-Enzyme Intermediate of Human Pancreatic α-Amylase<sup>,</sup>","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Covalent bond; Stereochemistry; Glycosyl; Hydrolase; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625705,0.0002427137,0.0002219146,0.00005376331,0.00007771963,0.00004426672,0.0002648794,0.0001882608,0.00005207278],"category_scores_gemma":[0.0001740283,0.0002075385,0.00008017766,0.0002557149,0.00006964538,0.00001249744,0.00006110839,0.0001481691,0.000008995476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004443906,"about_ca_system_score_gemma":0.000101658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001397463,"about_ca_topic_score_gemma":0.000007936843,"domain_scores_codex":[0.9985444,0.00007235673,0.0004555578,0.0004617758,0.0002056232,0.0002603191],"domain_scores_gemma":[0.9990354,0.000009483376,0.0002012205,0.0004684558,0.0001784261,0.0001069916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001800334,0.00008745379,0.0004390598,0.00004493058,0.00002213562,0.000002740183,0.0001723073,0.00004106396,0.996892,0.00001621998,0.0004576407,0.001644369],"study_design_scores_gemma":[0.0005284274,0.0003729657,0.02992956,0.00007008829,0.00001860023,0.00001813954,0.0001554574,0.00005111593,0.9681965,0.00003552842,0.0003967676,0.0002268135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985691,0.0001252134,0.00002894495,0.0004885793,0.00007556316,0.0003169154,0.00004457157,0.00003649976,0.0003145761],"genre_scores_gemma":[0.9971469,0.00006198551,0.00005389918,0.0004386877,0.0004820441,0.00003091592,0.001083468,0.00002016308,0.0006819058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0294905,"threshold_uncertainty_score":0.8463174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007949869168922588,"score_gpt":0.2448993091247292,"score_spread":0.2369494399558066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}