{"id":"W1966286622","doi":"10.1021/bi901400p","title":"Directed “<i>in Situ</i>” Inhibitor Elongation as a Strategy To Structurally Characterize the Covalent Glycosyl-Enzyme Intermediate of Human Pancreatic α-Amylase<sup>,</sup>","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Covalent bond; Stereochemistry; Glycosyl; Hydrolase; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265137,0.0005441412,0.0001729643,0.00006609121,0.0001259308,0.0002600704,0.0002930072,0.0002648644,0.001126351],"category_scores_gemma":[0.0001419543,0.0001512111,0.0002411006,0.0000752879,0.0002257751,0.0002246608,0.0001640029,0.0005273897,0.0004026272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002606624,"about_ca_system_score_gemma":0.0001282146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004951818,"about_ca_topic_score_gemma":0.0005534716,"domain_scores_codex":[0.999893,0.0000222593,0.000005968614,0.00003500767,0.00002076024,0.00002305511],"domain_scores_gemma":[0.9998891,0.00002136029,0.00005280897,0.00001605543,0.00001074308,0.000009850571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004179478,0.000008702798,0.00007383254,0.00002147048,0.000003475097,0.000022388,0.0000139397,0.00007779745,0.9985506,0.000152666,0.00002387815,0.001009492],"study_design_scores_gemma":[0.000001879589,0.00005605926,0.0001624025,8.616981e-7,0.000004107044,0.00008154684,0.000005503391,0.0001900655,0.9983243,0.00001657978,0.001155198,0.000001359374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9136508,0.002183403,0.07855246,0.0001658721,0.00004936311,0.00008866788,0.0004183865,0.0002317287,0.004659465],"genre_scores_gemma":[0.9663884,0.001085385,0.027463,0.0001037161,0.00001370877,0.00005647568,0.000730667,0.00008469696,0.004074057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126351,"threshold_uncertainty_score":0.003768027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007949869168922588,"score_gpt":0.2448993091247292,"score_spread":0.2369494399558066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}