{"id":"W1966326873","doi":"10.1021/ol047814v","title":"Catalytic Enantioselective Alkynylation of Prochiral sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":365,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Alkynylation; Chemistry; Enantioselective synthesis; Catalysis; Nitrogen atom; Nitrogen; Asymmetric carbon; Copper; Atom (system on chip); Optically active; Medicinal chemistry; Carbon fibers; Carbon atom; Stereochemistry; Ring (chemistry); Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193018,0.0005251039,0.0002734725,0.0001586246,0.0001738625,0.0001858949,0.000449864,0.000245148,0.001435746],"category_scores_gemma":[0.0001492949,0.0001441155,0.0001863778,0.0001547225,0.0003176132,0.0002535426,0.0003726287,0.000492318,0.0005118042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582259,"about_ca_system_score_gemma":0.0002366475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007953406,"about_ca_topic_score_gemma":0.001312105,"domain_scores_codex":[0.9998492,0.00001865282,0.000007211287,0.000034693,0.00002840686,0.00006184312],"domain_scores_gemma":[0.999949,0.00000994093,0.00001584356,0.000008964752,0.000007284171,0.000009023981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414116,0.00004989814,0.0002349793,0.0001875529,0.00001882209,0.0005986925,0.0001075699,0.0007583713,0.9810008,0.004010646,0.0007403072,0.01215084],"study_design_scores_gemma":[0.00002762042,0.0001613554,0.0004794408,0.000003251303,0.000007336014,0.0003538454,0.00001865917,0.0008631457,0.9934782,0.0002783847,0.004319093,0.000009646521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9400388,0.002369737,0.02553377,0.0001953479,0.0002358367,0.0001375035,0.0005287243,0.000400568,0.0305597],"genre_scores_gemma":[0.9905413,0.0008672934,0.005656389,0.00004849402,0.00001960068,0.00002699464,0.0001720985,0.00003062604,0.002637133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435746,"threshold_uncertainty_score":0.004803061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029199817811523,"score_gpt":0.2391214304139277,"score_spread":0.2288294322358125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}