{"id":"W1966330905","doi":"10.1139/o2012-001","title":"Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death","year":2012,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Sphingolipid; Ceramide; Programmed cell death; Reactive oxygen species; Fenretinide; Apoptosis; Sphingosine; Cell biology; Trolox; Ascorbic acid; Jurkat cells; Cancer cell; Viability assay; Biology; Biochemistry; Chemistry; Retinoid; Antioxidant; Immunology; Cancer; Retinoic acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002945213,0.0005937107,0.000496069,0.0006015403,0.0001560499,0.0003200675,0.0003043599,0.0005375901,0.0009589362],"category_scores_gemma":[0.0002072164,0.0002130642,0.0004263702,0.0002430298,0.0003023622,0.0004171241,0.0003181406,0.000560194,0.0003092991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352926,"about_ca_system_score_gemma":0.0001801118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002938938,"about_ca_topic_score_gemma":0.0003245497,"domain_scores_codex":[0.9995818,0.00007136088,0.00005176985,0.00008032231,0.0001295369,0.00008529562],"domain_scores_gemma":[0.9997498,0.00002586883,0.0001133376,0.0000315426,0.0000431926,0.00003631754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004392035,0.00003675444,0.0007719204,0.00007260866,0.00001072546,0.0002878391,0.0000303564,0.00004348685,0.9957621,0.0001023921,0.00001431335,0.002428396],"study_design_scores_gemma":[0.00002125772,0.00061188,0.02054664,0.00001193873,0.00002733184,0.001523872,0.00006047341,0.0003475176,0.9751975,0.0001780624,0.001464053,0.000009516584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748237,0.01402408,0.007521991,0.0001166228,0.00003790495,0.0001402943,0.0006031024,0.0001859727,0.002546372],"genre_scores_gemma":[0.9923744,0.002587542,0.002688097,0.00008511636,0.00002142242,0.000097401,0.0005595752,0.00001466359,0.0015718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009589362,"threshold_uncertainty_score":0.003207982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437243851265847,"score_gpt":0.2459558093071823,"score_spread":0.2315833707945238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}