{"id":"W1966351884","doi":"10.1016/j.ejmech.2012.02.042","title":"Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Cancer Institute; Canadian Institutes of Health Research; Institute of Materials Research and Engineering; Saskatchewan Health Research Foundation","keywords":"Chemistry; Multiple drug resistance; Cytotoxicity; Cytotoxic T cell; Apoptosis; Flow cytometry; DNA fragmentation; In vitro; Stereochemistry; Cell cycle; Cancer cell; Topoisomerase; Molecular biology; Cancer; Programmed cell death; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011881,0.0002446075,0.0002713892,0.0001093001,0.0001616264,0.0002286333,0.0004651426,0.0002041985,0.001319454],"category_scores_gemma":[0.0001025048,0.0001073227,0.00009285664,0.0001179703,0.000175764,0.0001802736,0.000353419,0.0004434982,0.0005772713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003278105,"about_ca_system_score_gemma":0.0002112417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002757706,"about_ca_topic_score_gemma":0.0004060434,"domain_scores_codex":[0.9999337,0.00001386544,0.000003191428,0.00001572748,0.00001382157,0.00001968288],"domain_scores_gemma":[0.9999506,0.000003780902,0.00001339994,0.000006801777,0.000005798912,0.00001951707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006251021,0.00008226182,0.0002758669,0.0001641404,0.00001187179,0.0001771644,0.0001056339,0.001260956,0.9795412,0.002139485,0.00123741,0.01437886],"study_design_scores_gemma":[0.0002780251,0.002484938,0.003118793,0.00002046954,0.00005149149,0.0008731539,0.00006735879,0.00628254,0.9456757,0.0006048921,0.04050554,0.00003704979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742489,0.002770536,0.01429014,0.000263126,0.00008052409,0.00009872061,0.0003981075,0.0005236743,0.007326253],"genre_scores_gemma":[0.9880595,0.00111448,0.005997036,0.00009662889,0.00001703524,0.00007940672,0.0003907962,0.00002906735,0.004216021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001319454,"threshold_uncertainty_score":0.004414082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186838367758064,"score_gpt":0.2469479108071295,"score_spread":0.2250795271295489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}