{"id":"W1966388845","doi":"10.1128/jvi.06112-11","title":"HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Immunology; Biology; Human leukocyte antigen; Interleukin 21; Jurkat cells; Interleukin 12; Antibody; Flow cytometry; Degranulation; Cytotoxic T cell; Immune system; T cell; Antigen; Receptor; In vitro; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351346,0.0002581624,0.0002888977,0.0001299317,0.0001345354,0.0002870245,0.0002065934,0.0002560584,0.00263578],"category_scores_gemma":[0.0001613978,0.0001642136,0.0001943595,0.00009905246,0.0001734722,0.0001834741,0.0002047883,0.0007763447,0.0004059078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712821,"about_ca_system_score_gemma":0.000180651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000436589,"about_ca_topic_score_gemma":0.0005107338,"domain_scores_codex":[0.9997745,0.00004219618,0.00002227386,0.00002594074,0.00003368382,0.0001013343],"domain_scores_gemma":[0.9999121,0.00003113855,0.00001304548,0.00001272136,0.000006969052,0.00002410919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005213389,0.0002077377,0.0003926257,0.00004298315,0.00001015358,0.00009345808,0.00003140213,0.00008834386,0.9953707,0.0001669036,0.00006621415,0.003007964],"study_design_scores_gemma":[0.0001861652,0.003574786,0.01908431,0.00002113057,0.00004814831,0.001166699,0.0000844856,0.001933067,0.9706335,0.0002026157,0.003051964,0.00001304807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980423,0.0004791617,0.0004143569,0.00003292189,0.00001918944,0.00002167192,0.0001045893,0.00002283312,0.0008629267],"genre_scores_gemma":[0.9979679,0.0002690705,0.0004359528,0.00003938343,0.000007083487,0.00003437696,0.0001713393,0.000006941414,0.001067853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00263578,"threshold_uncertainty_score":0.008817554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166978053529417,"score_gpt":0.2743834054760636,"score_spread":0.2627136249407694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}