{"id":"W1966388845","doi":"10.1128/jvi.06112-11","title":"HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Immunology; Biology; Human leukocyte antigen; Interleukin 21; Jurkat cells; Interleukin 12; Antibody; Flow cytometry; Degranulation; Cytotoxic T cell; Immune system; T cell; Antigen; Receptor; In vitro; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005994606,0.0002616044,0.0004949442,0.0003319809,0.0002679443,0.00001738577,0.0002226038,0.000256348,0.003512164],"category_scores_gemma":[0.0001706661,0.0001834646,0.0003212726,0.0002306802,0.0002036699,0.0006955958,0.0001048932,0.001188068,0.000978402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269936,"about_ca_system_score_gemma":0.00007820639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006085301,"about_ca_topic_score_gemma":0.00001000507,"domain_scores_codex":[0.9977926,0.000540871,0.0008994523,0.0001977284,0.0001172974,0.0004520474],"domain_scores_gemma":[0.9980721,0.0003644438,0.0008840688,0.0002568204,0.0003667134,0.00005583528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007809022,0.0006054743,0.01442252,0.00001231032,0.0004173749,0.000003197683,0.000870834,0.0002469318,0.9498708,0.0001337167,0.03253312,0.0001027616],"study_design_scores_gemma":[0.001346583,0.0004657037,0.09002553,0.00004103841,0.0002049391,0.0009538272,0.0008783048,0.00001655327,0.7563343,0.00003481586,0.1494918,0.0002066326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508667,0.001264034,0.00389168,0.001293247,0.04192638,0.0002105414,0.000006546463,0.00002597122,0.0005149189],"genre_scores_gemma":[0.9926432,0.0003237539,0.00007476621,0.0008396032,0.0005238977,0.000007551568,0.00008613683,0.00002404285,0.005477063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1935365,"threshold_uncertainty_score":0.9997994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166978053529417,"score_gpt":0.2743834054760636,"score_spread":0.2627136249407694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}