{"id":"W1966397048","doi":"10.1038/ncb1280","title":"A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling","year":2005,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Terry Fox Foundation","keywords":"Pleckstrin homology domain; Cell biology; Biology; Rac GTP-Binding Proteins; GTPase; Regulator; GTP'; Signal transduction; Biochemistry; RAC1","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302978,0.0003893944,0.0004600129,0.000291809,0.0004168057,0.0005662325,0.0005289601,0.0006527254,0.001966038],"category_scores_gemma":[0.00028555,0.0002825147,0.0005277148,0.0002065573,0.0004854456,0.0004192035,0.0005842402,0.001005876,0.001594778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005059253,"about_ca_system_score_gemma":0.0002818905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006413779,"about_ca_topic_score_gemma":0.0008091392,"domain_scores_codex":[0.9998901,0.00001160457,0.00001042108,0.00002526917,0.00003231575,0.00003034294],"domain_scores_gemma":[0.9997467,0.0000506303,0.00005347615,0.00003092452,0.00001767104,0.0001005091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002493722,0.00001606253,0.0003634016,0.0000347173,0.000007308419,0.0006868941,0.00001752996,0.0001356515,0.9965671,0.0003970687,0.000103513,0.001421247],"study_design_scores_gemma":[0.000112261,0.0001267428,0.02801877,0.0000167275,0.00004170672,0.006761495,0.00009186166,0.003932839,0.9533301,0.001009979,0.006504975,0.00005249026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827213,0.0008348399,0.01310246,0.0001911362,0.00006966091,0.00002680872,0.0008084279,0.0004017687,0.001843629],"genre_scores_gemma":[0.9945109,0.0001288709,0.003474959,0.00008152569,0.000009555532,0.00001339758,0.0009153517,0.00005826989,0.0008071097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966038,"threshold_uncertainty_score":0.006577015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009865336457616024,"score_gpt":0.2552893798773456,"score_spread":0.2454240434197296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}