{"id":"W1966409656","doi":"10.1016/j.bmc.2007.10.060","title":"Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Potency; Pharmacology; Pharmacokinetics; In vitro; Indole test; In vivo; Structure–activity relationship; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004120191,0.0001624514,0.0002440273,0.000050364,0.0000278832,0.000004023072,0.0001079219,0.0001876907,0.00002031031],"category_scores_gemma":[0.0002262748,0.0001627853,0.00006237695,0.0001828406,0.0001285435,0.000004811661,0.00005740153,0.0000837987,1.248204e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002284574,"about_ca_system_score_gemma":0.0001048518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001938293,"about_ca_topic_score_gemma":0.000002104938,"domain_scores_codex":[0.9988618,0.00001594484,0.0004712928,0.0002628682,0.0001711615,0.0002168569],"domain_scores_gemma":[0.9993395,0.00002958479,0.000223702,0.0001616825,0.0001381426,0.0001073719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006257828,0.0001083581,0.0003467143,0.0002052594,0.00001883008,0.000003619974,0.00004910276,0.0002671604,0.9944449,0.000003473248,0.00003815718,0.003888653],"study_design_scores_gemma":[0.002844656,0.00009263805,0.0004473958,0.00008228052,0.00003903348,0.00001758244,0.000113191,0.0004948772,0.9953386,0.00001068857,0.0003722928,0.0001467663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886823,0.00202781,0.008789194,0.00006259506,0.00006730259,0.0002531849,0.00002461229,0.000007391917,0.00008556993],"genre_scores_gemma":[0.9969195,0.0001417263,0.002425379,0.00005550242,0.0001999064,0.000006114286,0.0001868672,0.00002251076,0.00004254108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008237113,"threshold_uncertainty_score":0.6638194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101024854654155,"score_gpt":0.2629074239100518,"score_spread":0.2528049384446364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}