{"id":"W1966421968","doi":"10.1373/clinchem.2008.103200","title":"Enhancing Newborn Screening for Tyrosinemia Type I","year":2008,"lang":"en","type":"letter","venue":"Clinical Chemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centers for Disease Control and Prevention","keywords":"Tyrosinemia; Newborn screening; Tyrosine; Asymptomatic; Medicine; Inborn error of metabolism; Internal medicine; Endocrinology; Incidence (geometry); Pediatrics; Gastroenterology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002888324,0.0004212393,0.0005737701,0.0000160754,0.0001102958,0.0000315256,0.0005559711,0.002247317,0.0001158983],"category_scores_gemma":[0.001192095,0.0004321553,0.0004690712,0.0000881726,0.0002355089,0.00000177452,0.0001823363,0.0009662189,0.00002444514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003619716,"about_ca_system_score_gemma":0.0003403025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002615744,"about_ca_topic_score_gemma":0.000001084,"domain_scores_codex":[0.9974436,0.00004992667,0.0007832049,0.0009725603,0.0002115758,0.0005391393],"domain_scores_gemma":[0.998297,0.0001303914,0.000302252,0.0008949989,0.0002355452,0.0001397653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000768305,0.00002891936,0.0004598171,0.0002309343,0.0001124754,0.00001140156,0.000002429344,0.000002956043,0.01772497,2.863507e-7,0.9771419,0.004207115],"study_design_scores_gemma":[0.0007422284,0.00008166021,0.00007251913,0.00005691244,0.00009258254,0.00001843278,0.000006970567,0.000006895516,0.04685513,0.00002703441,0.951564,0.0004757044],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2364548,0.08731324,0.1362377,0.4523551,0.01895982,0.006015203,0.002983534,0.0006981819,0.05898238],"genre_scores_gemma":[0.001070241,0.005610046,0.07097688,0.7282311,0.0658851,0.0001721963,0.01757693,0.0004519846,0.1100256],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.275876,"threshold_uncertainty_score":0.999813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04729971870610953,"score_gpt":0.3380356851576042,"score_spread":0.2907359664514946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}