{"id":"W1966421968","doi":"10.1373/clinchem.2008.103200","title":"Enhancing Newborn Screening for Tyrosinemia Type I","year":2008,"lang":"en","type":"letter","venue":"Clinical Chemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centers for Disease Control and Prevention","keywords":"Tyrosinemia; Newborn screening; Tyrosine; Asymptomatic; Medicine; Inborn error of metabolism; Internal medicine; Endocrinology; Incidence (geometry); Pediatrics; Gastroenterology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001257406,0.0005946154,0.0006459564,0.001393117,0.0005701717,0.0008096567,0.0008129652,0.0008798006,0.005770694],"category_scores_gemma":[0.006275327,0.0001279344,0.0004245162,0.0003848356,0.0002494296,0.0007233222,0.001042592,0.001117796,0.001457037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002250454,"about_ca_system_score_gemma":0.002313724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03465812,"about_ca_topic_score_gemma":0.02502702,"domain_scores_codex":[0.998915,0.0002576359,0.00007178772,0.0001433748,0.0003337435,0.0002784479],"domain_scores_gemma":[0.998667,0.0002641017,0.0001125962,0.00003512169,0.0005341424,0.0003870282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006218171,0.0006356477,0.3451977,0.001149532,0.00008742418,0.01302194,0.001550144,0.0006750392,0.01035659,0.003220436,0.105333,0.5181506],"study_design_scores_gemma":[0.0001837845,0.00310123,0.5403862,0.0102589,0.000573279,0.05379374,0.004242116,0.008317501,0.02290849,0.006229791,0.3498192,0.0001858443],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6214645,0.09103167,0.03889541,0.05055119,0.004536598,0.002126795,0.005486632,0.004507262,0.1813999],"genre_scores_gemma":[0.9131001,0.0327247,0.02732544,0.01329004,0.001150839,0.0005818694,0.001761342,0.0002193894,0.0098462],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.03465812,"threshold_uncertainty_score":0.0689128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04729971870610953,"score_gpt":0.3380356851576042,"score_spread":0.2907359664514946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}