{"id":"W1966443620","doi":"10.1074/jbc.m809116200","title":"Noncanonical Activation of Akt/Protein Kinase B in β-Cells by the Incretin Hormone Glucose-dependent Insulinotropic Polypeptide","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Protein kinase B; Incretin; Internal medicine; Endocrinology; PI3K/AKT/mTOR pathway; Phosphorylation; mTORC1; Protein kinase A; Proto-Oncogene Proteins c-akt; Biology; Signal transduction; Cell biology; Chemistry; Medicine; Type 2 diabetes; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899629,0.0003338451,0.0001353019,0.0001646677,0.0001561132,0.0003823447,0.0001110628,0.0001478335,0.001338237],"category_scores_gemma":[0.0001371044,0.0001703545,0.0001798895,0.0001187094,0.0002935861,0.0003046572,0.0002428172,0.0006394977,0.0004175675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689002,"about_ca_system_score_gemma":0.0002785622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001440902,"about_ca_topic_score_gemma":0.0003197564,"domain_scores_codex":[0.9999095,0.00001828962,0.000008134894,0.00001951858,0.00002696105,0.00001757946],"domain_scores_gemma":[0.9999456,0.00001046367,0.00001387082,0.000008947665,0.000006326223,0.00001480048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003086761,0.00006072909,0.0006575771,0.0001530368,0.00001472467,0.0001775511,0.00002143391,0.0001111186,0.9913002,0.001217777,0.0001342012,0.005842886],"study_design_scores_gemma":[0.0001511897,0.0005048512,0.01247545,0.00003393609,0.00004113871,0.001144195,0.00005885064,0.001795916,0.9710479,0.001349314,0.011387,0.00001033205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753675,0.0121052,0.007502478,0.0006378276,0.0001612127,0.00004111189,0.0002777365,0.0001126756,0.003794254],"genre_scores_gemma":[0.9852623,0.007535157,0.004858854,0.0001638975,0.00004089174,0.00003100309,0.0002887953,0.00001300913,0.00180604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338237,"threshold_uncertainty_score":0.004476845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389335731923814,"score_gpt":0.2420778996360587,"score_spread":0.2281845423168206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}