{"id":"W1966445473","doi":"10.1038/mtna.2012.55","title":"Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Zinc finger nuclease; Integrase; Myogenesis; Genetic enhancement; Biology; Insertional mutagenesis; Transplantation; Gene targeting; Molecular biology; Cell biology; Gene; Cancer research; Myocyte; Genome editing; Genetics; CRISPR; Genome; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007548301,0.0001818477,0.0001589313,0.0000841217,0.00003528297,0.00001414798,0.0001630318,0.0001470492,0.0001427777],"category_scores_gemma":[0.000004677956,0.0001941475,0.0001089146,0.0001198964,0.00005148706,0.000007588921,0.00001990724,0.00008938801,0.00001356073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000132307,"about_ca_system_score_gemma":0.00001327636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246366,"about_ca_topic_score_gemma":0.00002023728,"domain_scores_codex":[0.9990283,0.00005185457,0.0002781485,0.0002878701,0.0001225826,0.0002313017],"domain_scores_gemma":[0.999584,0.000003579941,0.00006458539,0.0002355946,0.00005788014,0.00005433957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002187954,0.00007154427,0.0001517972,0.00002115783,0.00003523938,0.000006771845,0.0001118791,0.0006382317,0.9934427,0.000008203769,0.00005299955,0.005437585],"study_design_scores_gemma":[0.001056994,0.0002722744,0.03096676,0.00001416071,0.000008830838,0.0000126116,0.00002780421,0.0001959534,0.9664128,0.00006087905,0.0007667184,0.0002042389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676098,0.0007897348,0.03108827,0.00004067602,0.00005681673,0.0002857669,0.00002557354,0.00001545013,0.00008795405],"genre_scores_gemma":[0.9967685,0.0002257736,0.002281286,0.0001065722,0.00005795157,0.00004176337,0.0004454645,0.00004205593,0.00003066973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03081496,"threshold_uncertainty_score":0.7917107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003712537081160202,"score_gpt":0.2323689209129772,"score_spread":0.228656383831817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}