{"id":"W1966462640","doi":"10.1073/pnas.1407849111","title":"Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Ubiquitin; Lysine; Biochemistry; Cell biology; Ubiquitin-conjugating enzyme; Linkage (software); Chemistry; Biology; Ubiquitin ligase; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032481,0.0002045734,0.0001350111,0.00007030004,0.0001798869,0.0002321652,0.0001649605,0.0002657976,0.001102014],"category_scores_gemma":[0.0001172641,0.00007181211,0.0002085034,0.0000362793,0.0001655017,0.000209306,0.0002443015,0.0001655028,0.0004538061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050149,"about_ca_system_score_gemma":0.0001353417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000196736,"about_ca_topic_score_gemma":0.0001794244,"domain_scores_codex":[0.9999497,0.000008371907,0.00000560943,0.00001233833,0.00001008424,0.0000138021],"domain_scores_gemma":[0.9999255,0.00001203376,0.00002402312,0.00001099521,0.000007169246,0.00002028637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001245151,0.00001532273,0.000458837,0.00001631268,0.000002314393,0.0001346548,0.00001188534,0.0001412635,0.9977987,0.0002509683,0.00001230208,0.00103285],"study_design_scores_gemma":[0.00001179483,0.0001899762,0.004901543,0.000004570819,0.000007023051,0.0004338108,0.00002664609,0.0008428104,0.9923441,0.00009887429,0.001134662,0.000004280505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975981,0.0003339185,0.001319607,0.00003464683,0.000005539159,0.000004766277,0.00003656793,0.0000248995,0.0006418111],"genre_scores_gemma":[0.9990269,0.0001208827,0.0004670247,0.000009343786,0.000002027781,0.000002541626,0.00004987957,0.000002437925,0.0003190228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102014,"threshold_uncertainty_score":0.003686547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239167723192685,"score_gpt":0.2877175995428532,"score_spread":0.2638008272235847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}