{"id":"W1966474816","doi":"10.1053/j.seminhematol.2005.05.002","title":"Pharmacology of 5-Aza-2′-deoxycytidine (decitabine)","year":2005,"lang":"en","type":"review","venue":"Seminars in Hematology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":232,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Deoxycytidine; Azacitidine; Ribonucleotide reductase; Decitabine; Deoxycytidine kinase; Cytidine; Pharmacology; Cytidine deaminase; Mechanism of action; Carmustine; Methyltransferase; Floxuridine; Chemistry; Medicine; Biochemistry; DNA methylation; Enzyme; Methylation; Internal medicine; Etoposide; DNA; Cancer; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004019052,0.0004195896,0.001652836,0.000320267,0.00002515158,0.000004165015,0.0004329143,0.001018337,0.0001128487],"category_scores_gemma":[0.0001431501,0.0004034822,0.000359713,0.0002832585,0.0001756298,0.00000220058,0.00024067,0.0003077622,0.00002619433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004237199,"about_ca_system_score_gemma":0.0002466431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006772386,"about_ca_topic_score_gemma":0.00002162528,"domain_scores_codex":[0.9974807,0.0002950949,0.001065775,0.0006189357,0.0001217565,0.0004177189],"domain_scores_gemma":[0.9986604,0.0001380431,0.0005456068,0.0005017533,0.00007513976,0.0000790574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003693726,0.0002445854,0.000154594,0.004901219,0.0001912709,0.00004375078,0.0000370426,0.00002266531,0.003052718,0.0003664651,0.002368408,0.9885803],"study_design_scores_gemma":[0.0003479735,0.0001951181,0.000003457324,0.001412504,0.0001965575,0.0001109919,0.000008763766,0.000006299691,0.01109096,0.00007344745,0.9862131,0.0003408418],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001695501,0.9960139,0.00007381531,0.00002561132,0.0005948058,0.0005228903,0.00003934785,0.000008734048,0.00102537],"genre_scores_gemma":[0.0008174411,0.9967347,0.001124962,0.00002611898,0.0003875985,0.0001166841,0.0003829293,0.00006767485,0.0003419219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9882395,"threshold_uncertainty_score":0.9998417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0303030763665276,"score_gpt":0.3697691024252496,"score_spread":0.339466026058722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}