{"id":"W1966500657","doi":"10.1371/journal.pone.0024792","title":"Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"U.S. Public Health Service; National Institutes of Health; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Genipin; Warburg effect; Breast cancer; Cancer; Function (biology); Cancer research; Breast tumor; Oncology; Internal medicine; Medicine; Biology; Cell biology; Cancer cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137833,0.00009816267,0.0002097938,0.00003812558,0.00001826811,0.000003057876,0.00006451936,0.00007264378,0.00002161511],"category_scores_gemma":[0.00001967606,0.00009033675,0.00003530024,0.00004697701,0.00003281704,0.000007711635,0.00006094647,0.000054244,3.687367e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005181654,"about_ca_system_score_gemma":0.00002784548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001151361,"about_ca_topic_score_gemma":0.0000188195,"domain_scores_codex":[0.9993215,0.00003606637,0.0001861107,0.0002056308,0.0001202855,0.0001304422],"domain_scores_gemma":[0.9996419,0.000004108672,0.0001102589,0.0001353258,0.00006960381,0.00003879296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002419244,0.0002516816,0.002941092,0.0003620122,0.00006067339,1.669955e-7,0.0001702217,0.000009472988,0.9952626,0.000002449491,0.00009135667,0.0006063381],"study_design_scores_gemma":[0.0005728497,0.0001009864,0.0025568,0.000157733,0.00009970962,7.160522e-7,0.00001361438,0.001553768,0.9948174,0.00001917383,0.0000170595,0.00009014069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924266,0.007061613,0.00005487733,0.00001074306,0.00008467947,0.0002200389,0.0000874224,0.000004240247,0.00004973328],"genre_scores_gemma":[0.9986188,0.0009000255,0.0000728211,0.00001226029,0.0001112615,0.00004033972,0.00002609541,0.00001458373,0.0002038328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006192128,"threshold_uncertainty_score":0.3683826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956264992723089,"score_gpt":0.2107866237073859,"score_spread":0.191223973780155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}