{"id":"W1966555773","doi":"10.1172/jci77888","title":"Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Key Research and Development Program of China; Canadian Institutes of Health Research; National Institutes of Health; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China; Fondation Brain Canada","keywords":"Long-term potentiation; AMPA receptor; Endocytosis; Neuroscience; Postsynaptic potential; Hippocampal formation; Biology; Chemistry; Cell biology; NMDA receptor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138592,0.000383091,0.0004758416,0.0002144274,0.0001920313,0.0003485205,0.0003629854,0.0003665528,0.0004551063],"category_scores_gemma":[0.0002366168,0.0001612042,0.000444155,0.0001256513,0.0003605785,0.0004303222,0.0003273405,0.0008985157,0.0002722595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004974047,"about_ca_system_score_gemma":0.0003121477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000657179,"about_ca_topic_score_gemma":0.0006062629,"domain_scores_codex":[0.9998241,0.00001460268,0.00002443642,0.00003311221,0.00006312875,0.00004058486],"domain_scores_gemma":[0.9998773,0.000009655067,0.00005047486,0.000016998,0.00002282413,0.00002281157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004105696,0.00006440072,0.001042541,0.0001526415,0.00003059041,0.0003282684,0.00003920484,0.0001039077,0.9843661,0.0006384865,0.0001136208,0.01270968],"study_design_scores_gemma":[0.0001175081,0.001105609,0.07355323,0.00006923088,0.0001004054,0.004067034,0.0001153921,0.001509117,0.9111901,0.001804265,0.006336712,0.00003141058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595462,0.02491273,0.01090387,0.0003269497,0.00009465554,0.0000722223,0.0002633087,0.0001900753,0.003690009],"genre_scores_gemma":[0.9903273,0.00574907,0.00128993,0.0000857827,0.00002501381,0.0000606946,0.0001716974,0.00001065357,0.002279756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000657179,"threshold_uncertainty_score":0.003608882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1212780480220481,"score_gpt":0.4145816233990266,"score_spread":0.2933035753769785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}