{"id":"W1966567607","doi":"10.3390/v6093377","title":"Is Resistance to Dolutegravir Possible When This Drug Is Used in First-Line Therapy?","year":2014,"lang":"en","type":"review","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Gilead Sciences; Bristol-Myers Squibb","keywords":"Dolutegravir; Integrase; Integrase inhibitor; Drug resistance; Drug; Virology; Food and drug administration; Human immunodeficiency virus (HIV); Pharmacology; Medicine; Antiretroviral therapy; Pharmacotherapy; Resistance mutation; Viral load; Biology; Internal medicine; Genetics; Gene; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005952519,0.0004351701,0.001516389,0.001536376,0.0002333654,0.001181829,0.0007190371,0.001574976,0.002678736],"category_scores_gemma":[0.000798923,0.0002407748,0.000664082,0.00118776,0.0007941815,0.001276284,0.0004886532,0.002001249,0.001551226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845446,"about_ca_system_score_gemma":0.0006998592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008962909,"about_ca_topic_score_gemma":0.001780152,"domain_scores_codex":[0.9997209,0.00007070817,0.00004067188,0.00004630689,0.00009333309,0.00002811252],"domain_scores_gemma":[0.9996655,0.0001915264,0.00006020212,0.000009152991,0.00005465743,0.00001898457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006890295,0.00003908243,0.0003247492,0.01191588,0.00009963358,0.0006348055,0.0001163037,0.0001743593,0.001586065,0.004360195,0.02014613,0.9605339],"study_design_scores_gemma":[0.00002594472,0.00008535846,0.001115766,0.005566172,0.0001474059,0.009010833,0.0001864594,0.0001102737,0.0008257185,0.002831043,0.9800678,0.00002731378],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001591033,0.9980027,0.000106459,0.0005503641,0.0001154665,0.000002283842,0.000008478742,0.000004097378,0.001051161],"genre_scores_gemma":[0.001384698,0.9975768,0.0001113146,0.000352563,0.0001436805,0.000002690294,0.00001622764,0.000001328993,0.0004107063],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002678736,"threshold_uncertainty_score":0.008961201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08767629477125227,"score_gpt":0.3627778801964917,"score_spread":0.2751015854252394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}