{"id":"W1966567607","doi":"10.3390/v6093377","title":"Is Resistance to Dolutegravir Possible When This Drug Is Used in First-Line Therapy?","year":2014,"lang":"en","type":"review","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Gilead Sciences; Bristol-Myers Squibb","keywords":"Dolutegravir; Integrase; Integrase inhibitor; Drug resistance; Drug; Virology; Food and drug administration; Human immunodeficiency virus (HIV); Pharmacology; Medicine; Antiretroviral therapy; Pharmacotherapy; Resistance mutation; Viral load; Biology; Internal medicine; Genetics; Gene; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003743567,0.0007593159,0.00251024,0.0006128737,0.0001090579,0.00006340894,0.0003496278,0.0002938413,0.001829571],"category_scores_gemma":[0.00006681664,0.0005046973,0.0004738526,0.0006850046,0.00004912315,0.00008828775,0.00008691212,0.0003799547,0.003010846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000362849,"about_ca_system_score_gemma":0.0004563374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002076332,"about_ca_topic_score_gemma":0.0008839738,"domain_scores_codex":[0.9971074,0.0001285129,0.0009038756,0.0008165775,0.0005235335,0.000520125],"domain_scores_gemma":[0.9981829,0.0002894793,0.0002649481,0.000934749,0.00007320097,0.0002547168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001828256,0.0005157723,0.003248474,0.008483425,0.0008328204,0.0001641565,0.005011396,4.772799e-8,0.000001947885,0.00007266446,0.5580053,0.4234812],"study_design_scores_gemma":[0.001243725,0.00006211404,0.00005954201,0.01922792,0.0003626894,0.000005667211,0.00001291891,3.143294e-7,0.0001599558,0.0001010842,0.9782823,0.0004817598],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001708544,0.9902577,0.00001193908,0.003559673,0.0001963392,0.001918805,0.0001582932,0.0001124656,0.003613889],"genre_scores_gemma":[0.00001718144,0.8621412,0.001465283,0.003211241,0.0002208208,0.0003701193,0.00009516183,0.0001141126,0.1323649],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4229995,"threshold_uncertainty_score":0.9997405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08767629477125227,"score_gpt":0.3627778801964917,"score_spread":0.2751015854252394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}