{"id":"W1966575304","doi":"10.1038/cdd.2014.224","title":"Parkin maintains mitochondrial levels of the protective Parkinson’s disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Fondation de France; Association France Parkinson; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Parkin; PINK1; Mitophagy; Mitochondrial fission; Mitochondrion; Biology; DNAJA3; Cell biology; mitochondrial fusion; Ubiquitin ligase; Ubiquitin; Molecular biology; Mitochondrial DNA; Biochemistry; Autophagy; Parkinson's disease; Apoptosis; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001919059,0.000169284,0.0002665793,0.0002438647,0.0002104155,0.0006659089,0.0001941095,0.0001694172,0.0008298683],"category_scores_gemma":[0.0002783033,0.0001403516,0.00009462778,0.0001397836,0.0002771589,0.0004570403,0.0001945562,0.0004037207,0.0002289887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003557306,"about_ca_system_score_gemma":0.0001920205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000402124,"about_ca_topic_score_gemma":0.0009348419,"domain_scores_codex":[0.9998598,0.00002278856,0.00001315713,0.00003922937,0.00002224674,0.00004280445],"domain_scores_gemma":[0.9996399,0.00003682403,0.0001238554,0.00005351124,0.00004757478,0.00009847153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004727018,0.00002901088,0.001329525,0.00001792821,0.000009171339,0.00005750249,0.00003228407,0.00004351939,0.9954814,0.0002090591,0.00004397082,0.002273967],"study_design_scores_gemma":[0.00003482345,0.000291022,0.01439541,0.000005433818,0.00003068583,0.0004430265,0.0001163411,0.0005837486,0.9815894,0.000286281,0.002217687,0.000006088967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975273,0.0007295994,0.001082741,0.00009812175,0.00001593645,0.000002427117,0.00009465821,0.00003997652,0.0004092882],"genre_scores_gemma":[0.9987675,0.0001471444,0.0002842326,0.00001116253,0.00000397448,0.000001603227,0.00009558858,0.00001324863,0.0006756718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008298683,"threshold_uncertainty_score":0.002776206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948716291226192,"score_gpt":0.2277150774386899,"score_spread":0.208227914526428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}