{"id":"W1966575304","doi":"10.1038/cdd.2014.224","title":"Parkin maintains mitochondrial levels of the protective Parkinson’s disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Fondation de France; Association France Parkinson; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Parkin; PINK1; Mitophagy; Mitochondrial fission; Mitochondrion; Biology; DNAJA3; Cell biology; mitochondrial fusion; Ubiquitin ligase; Ubiquitin; Molecular biology; Mitochondrial DNA; Biochemistry; Autophagy; Parkinson's disease; Apoptosis; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008237877,0.0001491065,0.0001375878,0.00003612577,0.00007621849,0.00001715703,0.0001037404,0.0001609038,0.00007884486],"category_scores_gemma":[0.0001340497,0.0001116992,0.00008133784,0.00008139454,0.0000550924,0.000005808665,0.00007832869,0.00008212424,0.00001210399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001748122,"about_ca_system_score_gemma":0.00009860961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001093731,"about_ca_topic_score_gemma":0.00002519742,"domain_scores_codex":[0.9989908,0.000193968,0.0002190074,0.0002990414,0.0001312264,0.0001659484],"domain_scores_gemma":[0.9992829,0.00001081102,0.0001482858,0.0002798752,0.0001153183,0.0001628067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009674008,0.0001413553,0.009327939,0.00003376403,0.00005550595,0.000002748551,0.0002605881,0.0001306399,0.9858862,0.00017325,0.002771542,0.000249138],"study_design_scores_gemma":[0.005450083,0.001075787,0.06322664,0.00004318588,0.0002703897,0.0000206038,0.0001017509,0.001972766,0.8867176,0.003035166,0.03753305,0.0005529683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944825,0.0006670938,0.002587924,0.00006439042,0.0008536277,0.0004965835,0.00005514116,0.00001235881,0.0007803927],"genre_scores_gemma":[0.9964993,0.00001944349,0.00009203961,0.00007533689,0.0001983245,0.00002910283,0.0001513966,0.00001470835,0.002920329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09916852,"threshold_uncertainty_score":0.4554962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948716291226192,"score_gpt":0.2277150774386899,"score_spread":0.208227914526428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}