{"id":"W1966585118","doi":"10.1371/journal.pone.0083190","title":"RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"Alberta Innovates","keywords":"Bromodomain; BRD4; Epigenetics; Apolipoprotein B; Inducer; BET inhibitor; Binding site; Chemistry; Acetylation; In vivo; Biology; Biochemistry; Cholesterol; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726354,0.0002162931,0.0003079459,0.0002132782,0.0001248569,0.0001801104,0.0001774474,0.00028441,0.002054099],"category_scores_gemma":[0.0001166849,0.0001181873,0.0001663843,0.000114687,0.0002063272,0.00008102224,0.0001270747,0.0005359537,0.0006016576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834439,"about_ca_system_score_gemma":0.0001145016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001660245,"about_ca_topic_score_gemma":0.000252453,"domain_scores_codex":[0.9999237,0.00002070101,0.000005706764,0.00001512329,0.00001982948,0.00001500704],"domain_scores_gemma":[0.9999635,0.000008994744,0.00001042443,0.000004459248,0.000002444432,0.0000101099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001926172,0.000353348,0.001227925,0.0001330171,0.00002970777,0.0004030911,0.00002710119,0.0001723678,0.9642925,0.0006395021,0.0007321269,0.03006316],"study_design_scores_gemma":[0.001090605,0.008439359,0.01749301,0.00002705161,0.00009928455,0.006420069,0.00005016222,0.001056609,0.9245218,0.0004094467,0.04036548,0.00002703936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816111,0.006911942,0.004136354,0.0005341735,0.0001152487,0.0001053669,0.0007174213,0.0002476453,0.005620746],"genre_scores_gemma":[0.9851683,0.002459705,0.004636618,0.0002792722,0.00003826684,0.0001228939,0.0009899422,0.00002817761,0.006276729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002054099,"threshold_uncertainty_score":0.006871641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025521576782595,"score_gpt":0.2369448331627485,"score_spread":0.2066896173949225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}