{"id":"W1966585118","doi":"10.1371/journal.pone.0083190","title":"RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"Alberta Innovates","keywords":"Bromodomain; BRD4; Epigenetics; Apolipoprotein B; Inducer; BET inhibitor; Binding site; Chemistry; Acetylation; In vivo; Biology; Biochemistry; Cholesterol; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008596487,0.00009535652,0.0001467258,0.00004953559,0.00002843321,0.00001753792,0.0001441899,0.0001245589,0.0002412775],"category_scores_gemma":[0.00003481335,0.00009463756,0.00003420429,0.0000738833,0.00005900378,0.000009590878,0.00005296164,0.00007580771,0.00003513727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009680966,"about_ca_system_score_gemma":0.00003099405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001853408,"about_ca_topic_score_gemma":0.00005060999,"domain_scores_codex":[0.9992332,0.00004951806,0.0002040137,0.0002223465,0.0001400363,0.0001508108],"domain_scores_gemma":[0.9994935,0.000003186825,0.00006713266,0.0003111816,0.00006357066,0.00006140798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000013776,0.0006686957,0.007681611,0.00002558934,0.00003244685,4.804798e-7,0.00009852996,1.713682e-7,0.9899341,0.00005600857,0.001150784,0.0003378234],"study_design_scores_gemma":[0.0004442476,0.0002430986,0.007302374,0.0000358413,0.00000894363,3.540129e-7,0.00006957631,0.00002407327,0.9907721,0.0001900504,0.0007854727,0.0001239068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997932,0.0001750096,0.00001790108,0.0003231161,0.00001740407,0.0002644805,0.00002080749,0.000007813203,0.001241434],"genre_scores_gemma":[0.9970387,0.00005362045,0.001492917,0.000402941,0.0001070602,0.00004590924,0.0001330937,0.00001551103,0.0007102342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475016,"threshold_uncertainty_score":0.3859208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025521576782595,"score_gpt":0.2369448331627485,"score_spread":0.2066896173949225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}