{"id":"W1966637800","doi":"10.1038/nri3401-c1","title":"IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist","year":2014,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; University of Toronto","funders":"","keywords":"Sialic acid; Downregulation and upregulation; DC-SIGN; Cell biology; Receptor; Immunology; Integrin; Fc receptor; Chemistry; Antibody; Dendritic cell; Biology; Immune system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002282297,0.0004265752,0.003336489,0.0001853736,0.0002265501,0.0000224181,0.0007314481,0.0006933246,0.000154893],"category_scores_gemma":[0.001136994,0.0001694207,0.0007497903,0.0004991734,0.001263474,0.00002614091,0.0004353837,0.002061296,0.0002666828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004280086,"about_ca_system_score_gemma":0.0002124729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002801899,"about_ca_topic_score_gemma":0.0000295702,"domain_scores_codex":[0.9963811,0.001348551,0.0009591345,0.0005157084,0.0004063049,0.0003892216],"domain_scores_gemma":[0.9971585,0.001006826,0.000530292,0.000985529,0.0002275934,0.00009127823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007873268,0.00002200535,5.283877e-7,0.008972601,0.0002944849,0.000005501849,0.0001801481,1.775607e-8,9.542274e-7,0.02164549,0.00454598,0.9642535],"study_design_scores_gemma":[0.0004349718,0.0002262012,0.00004760196,0.009843379,0.000595669,0.0004839466,0.00001444919,9.118624e-7,0.000001447556,0.0001163732,0.98808,0.0001550783],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002706025,0.9768274,0.000008720467,0.01625699,0.0006943596,0.002789635,0.00003729924,0.00001242659,0.0033704],"genre_scores_gemma":[0.00003206729,0.9950637,0.0001189236,0.0006104306,0.0007011237,0.0001854643,0.0000912516,0.00002870043,0.003168292],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.983534,"threshold_uncertainty_score":0.8955423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04458086266612349,"score_gpt":0.3870488485779879,"score_spread":0.3424679859118644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}