{"id":"W1966676795","doi":"10.1007/s00216-011-5389-1","title":"Development of single-chain variable fragment (scFv) antibodies against hapten benzo[a]pyrene: a binding study","year":2011,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Bundesministerium für Bildung und Forschung; Canada Research Chairs; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Immunoglobulin light chain; Chemistry; Hapten; Polyclonal antibodies; Paratope; Molecular biology; Pyrene; Antibody; Benzo(a)pyrene; Monoclonal antibody; clone (Java method); Oligonucleotide; Stereochemistry; DNA; Biochemistry; Biology; Organic chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004219631,0.0003285423,0.0002324019,0.0002218477,0.0002451719,0.0002013231,0.0005699011,0.0003945728,0.001255174],"category_scores_gemma":[0.0003508252,0.0002477551,0.00026664,0.0001852416,0.0001492078,0.0002978008,0.0001957202,0.0005341478,0.0004458739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795701,"about_ca_system_score_gemma":0.0001495812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002939183,"about_ca_topic_score_gemma":0.002346412,"domain_scores_codex":[0.9996771,0.0000570611,0.00001225682,0.00006280949,0.00009513074,0.00009571296],"domain_scores_gemma":[0.9997867,0.00009377697,0.0000160085,0.00001385258,0.00005580992,0.00003392608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004718877,0.00006503268,0.0001160637,0.00001773201,0.000005250172,0.00001837725,0.00002152147,0.00009246147,0.9985903,0.00006354899,0.00002691413,0.0009355909],"study_design_scores_gemma":[0.000009239308,0.0004096596,0.002307118,0.000002835386,0.00001512026,0.0001491379,0.00002587371,0.002075355,0.9934748,0.00003069849,0.001495199,0.000004983016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984721,0.0007328824,0.01273137,0.00006868508,0.00001459147,0.00005892544,0.00009684016,0.00004016155,0.001535577],"genre_scores_gemma":[0.9896736,0.000538526,0.00529829,0.00007972045,0.000006382427,0.00002921126,0.0003415739,0.00001390139,0.00401882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939183,"threshold_uncertainty_score":0.005844176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06783208253319917,"score_gpt":0.2959444551935346,"score_spread":0.2281123726603355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}