{"id":"W1966676795","doi":"10.1007/s00216-011-5389-1","title":"Development of single-chain variable fragment (scFv) antibodies against hapten benzo[a]pyrene: a binding study","year":2011,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Bundesministerium für Bildung und Forschung; Canada Research Chairs; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Immunoglobulin light chain; Chemistry; Hapten; Polyclonal antibodies; Paratope; Molecular biology; Pyrene; Antibody; Benzo(a)pyrene; Monoclonal antibody; clone (Java method); Oligonucleotide; Stereochemistry; DNA; Biochemistry; Biology; Organic chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004498887,0.0003363452,0.000762502,0.0001179629,0.000160085,0.00002981754,0.0001890282,0.0001822901,0.0008737777],"category_scores_gemma":[0.0001850829,0.0002413293,0.0001687295,0.0004087779,0.000476331,0.00005439237,0.0003200675,0.0003599106,0.00002734657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006662717,"about_ca_system_score_gemma":0.0001749861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006730992,"about_ca_topic_score_gemma":0.000007641206,"domain_scores_codex":[0.9973062,0.00002778657,0.0007802363,0.0005776369,0.0007202636,0.0005878573],"domain_scores_gemma":[0.9986739,0.0001291739,0.0001004509,0.0003099502,0.000199087,0.000587476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002758336,0.0142572,0.3122723,0.002836992,0.005033433,0.001049606,0.002998584,0.000001848404,0.6332409,0.004122113,0.0005843957,0.02084425],"study_design_scores_gemma":[0.008766488,0.003334584,0.0926177,0.001792781,0.003285801,0.0003257212,0.01211568,0.0150919,0.8437389,0.001017116,0.01504763,0.002865739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617082,0.0002066878,0.0001164336,0.0002405723,0.00002111494,0.0002291998,0.00001980141,0.00003605289,0.03742196],"genre_scores_gemma":[0.9899876,0.00005703937,0.005215772,0.000115752,0.0001001438,0.000009269675,0.00004038171,0.00002146311,0.004452555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2196546,"threshold_uncertainty_score":0.9841123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06783208253319917,"score_gpt":0.2959444551935346,"score_spread":0.2281123726603355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}