{"id":"W1966686539","doi":"10.1371/journal.pone.0063908","title":"Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; Agence Nationale de la Recherche; University of Alberta; Infrastructures en Biologie Santé et Agronomie","keywords":"Microtubule; Tubulin; In silico; Microtubule nucleation; Multiprotein complex; Cell biology; Biology; Biophysics; Chemistry; Computational biology; Centrosome; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002802316,0.0005878382,0.0008536499,0.0003891282,0.0002099922,0.000541943,0.0005584126,0.0003674065,0.0009987416],"category_scores_gemma":[0.0005109588,0.0001841361,0.0004140378,0.0002950103,0.0002816415,0.0002157792,0.0004133977,0.0003578678,0.0001694041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000434639,"about_ca_system_score_gemma":0.0002958809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006038503,"about_ca_topic_score_gemma":0.0005495905,"domain_scores_codex":[0.999827,0.00003805403,0.000007505941,0.00003286775,0.00007159437,0.00002305289],"domain_scores_gemma":[0.9998646,0.00005982244,0.00002380845,0.0000119972,0.00001618306,0.00002348931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0007389509,0.0004851733,0.001727929,0.0002632159,0.0001870669,0.000314456,0.00003426066,0.2044977,0.7601626,0.001376879,0.0003986611,0.02981303],"study_design_scores_gemma":[0.0001836638,0.002270972,0.002343597,0.00001396442,0.0002329133,0.0004421267,0.00003780789,0.5058831,0.4848807,0.0006184029,0.003043793,0.00004908079],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700913,0.001365343,0.02501959,0.0001186852,0.0000262905,0.00009357397,0.0002849163,0.0004557181,0.002544491],"genre_scores_gemma":[0.9878698,0.0005196588,0.01065062,0.00003355756,0.000004687335,0.00006261568,0.000279627,0.00002279714,0.0005566534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009987416,"threshold_uncertainty_score":0.003341079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02363229744051179,"score_gpt":0.2195876689578068,"score_spread":0.1959553715172951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}