{"id":"W1966691296","doi":"10.1074/jbc.c000611200","title":"Cloning and Characterization of PHIP, a Novel Insulin Receptor Substrate-1 Pleckstrin Homology DomainInteracting Protein","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Regional Laboratory Medicine Program","funders":"National Cancer Institute","keywords":"IRS1; Pleckstrin homology domain; Insulin receptor; Insulin receptor substrate; IRS2; GRB10; Biochemistry; Phosphotyrosine-binding domain; Tyrosine phosphorylation; Insulin; Tyrosine kinase; Biology; Receptor tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Phosphorylation; SH2 domain; Signal transduction; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222421,0.0003523818,0.0002074898,0.000226788,0.0001583313,0.0003324372,0.0002462601,0.000293998,0.00068434],"category_scores_gemma":[0.000196888,0.0001566495,0.0001972033,0.0002005027,0.0001956379,0.0002637179,0.000270073,0.0006154074,0.0008383723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698813,"about_ca_system_score_gemma":0.0002416465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004152145,"about_ca_topic_score_gemma":0.0003689857,"domain_scores_codex":[0.9999242,0.000006444488,0.00000494059,0.00002060832,0.00002618964,0.00001761295],"domain_scores_gemma":[0.9998983,0.00001426461,0.00002439281,0.0000115054,0.00001462824,0.00003686202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005403798,0.00003222862,0.000389533,0.00004668902,0.000005020413,0.0002828632,0.00002472902,0.00009045828,0.995572,0.0002222518,0.0001207185,0.003159523],"study_design_scores_gemma":[0.0000627566,0.0005092584,0.0379262,0.00002641556,0.00006013945,0.005822506,0.0001219764,0.003579489,0.9199209,0.0003368369,0.03161021,0.0000234594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800667,0.002509129,0.01329023,0.0004085174,0.00005988404,0.0001111937,0.001952867,0.00006623762,0.001535348],"genre_scores_gemma":[0.9567471,0.0033174,0.01718516,0.0002154323,0.00005818079,0.00007650654,0.01457083,0.00006071428,0.007768745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00068434,"threshold_uncertainty_score":0.002289355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562437609325593,"score_gpt":0.2401791540726952,"score_spread":0.2245547779794393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}