{"id":"W1966699402","doi":"10.1016/j.freeradbiomed.2012.09.010","title":"A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2–ARE pathway: Therapeutic implications for ALS","year":2012,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Acetamide; Oxidative stress; Chemistry; Molecule; Small molecule; Programmed cell death; Stereochemistry; Apoptosis; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005567019,0.0004281477,0.0004995055,0.00006254529,0.0004236805,0.00001438063,0.0005146671,0.000488964,0.000008190563],"category_scores_gemma":[0.001120052,0.000291526,0.0001154896,0.0001521531,0.0006361894,0.00001237291,0.0002107269,0.0004282118,0.000001437518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000409822,"about_ca_system_score_gemma":0.0001241994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005476964,"about_ca_topic_score_gemma":0.00001673163,"domain_scores_codex":[0.9978204,0.0002169864,0.0004260916,0.0006883275,0.00009647334,0.0007516881],"domain_scores_gemma":[0.9981416,0.0003888042,0.0003801507,0.0005669513,0.0002147252,0.0003077884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594723,0.0002475116,0.003019942,0.00004603694,0.0002130234,1.91784e-7,0.000275315,7.25342e-7,0.9890349,0.0008670131,0.0008799909,0.0052559],"study_design_scores_gemma":[0.002667326,0.000734424,0.01063773,0.00004786241,0.00007392814,0.000010588,0.0002898556,0.00001916694,0.9754192,0.001263754,0.008462559,0.0003735868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429795,0.009179028,0.04023056,0.00405892,0.0001765873,0.001816953,0.0007112445,0.00003906766,0.0008081039],"genre_scores_gemma":[0.9931299,0.0004188976,0.001831614,0.002404475,0.000870725,0.0005176578,0.0006720471,0.000048903,0.0001057746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05015037,"threshold_uncertainty_score":0.9999537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03550029845032347,"score_gpt":0.2912472762771758,"score_spread":0.2557469778268523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}