{"id":"W1966706075","doi":"10.1152/ajpheart.00723.2008","title":"Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"2-Methoxyestradiol; Vascular smooth muscle; Nitric oxide; Contraction (grammar); Endocrinology; Internal medicine; Muscle contraction; Cycloheximide; Chemistry; Rho kinase inhibitor; Endothelium; Contractility; Biology; Phosphorylation; Estrogen; Biochemistry; Rho-associated protein kinase; Protein biosynthesis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004491343,0.0006039154,0.0004468897,0.0002479772,0.0002153854,0.0002147714,0.0002245897,0.0002665765,0.001555712],"category_scores_gemma":[0.0002340101,0.000234789,0.0004531298,0.0002507929,0.0002095282,0.0001634173,0.0003186071,0.0007312423,0.0005335255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201582,"about_ca_system_score_gemma":0.0003163437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008442039,"about_ca_topic_score_gemma":0.001909023,"domain_scores_codex":[0.9997279,0.00007374553,0.00002303427,0.00003786473,0.00004297295,0.00009448961],"domain_scores_gemma":[0.9998038,0.00005991364,0.00004270571,0.00002372537,0.00002498232,0.00004482174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002377044,0.00006641471,0.00008416233,0.0000456976,0.000008595615,0.0000470985,0.00002255586,0.00003154562,0.9977564,0.00003220654,0.00004638758,0.001621391],"study_design_scores_gemma":[0.0001017554,0.002484977,0.009770577,0.00002073147,0.00003618523,0.0001837646,0.00004095701,0.0008438249,0.9824402,0.00003581353,0.004033118,0.000008068036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832922,0.01039643,0.002449473,0.0003107783,0.0001944128,0.00008000743,0.0003532252,0.0001118689,0.00281154],"genre_scores_gemma":[0.9664928,0.01410933,0.007102749,0.0003798506,0.0002100615,0.000224852,0.001671314,0.00005168607,0.009757363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555712,"threshold_uncertainty_score":0.00520438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006217080058407588,"score_gpt":0.2288179534026307,"score_spread":0.2226008733442231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}