{"id":"W1966717195","doi":"10.1016/j.febslet.2012.06.040","title":"Methamphetamine binds to α‐synuclein and causes a conformational change which can be detected by nanopore analysis","year":2012,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Circular dichroism; Methamphetamine; Conformational change; Alpha-synuclein; Chemistry; Biophysics; Dopaminergic; Nanopore; Drug; Dementia with Lewy bodies; Parkinson's disease; Biochemistry; Disease; Biology; Medicine; Dopamine; Neuroscience; Pharmacology; Dementia; Internal medicine; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008244549,0.0001763411,0.0001393141,0.0001485167,0.0002834177,0.0001729407,0.0001715091,0.0004783319,0.001356796],"category_scores_gemma":[0.0001446788,0.0001183795,0.0001769634,0.00008542483,0.0001831548,0.0002689971,0.0001923557,0.000327723,0.0004167757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013504,"about_ca_system_score_gemma":0.0000654918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004827616,"about_ca_topic_score_gemma":0.0006421268,"domain_scores_codex":[0.9998928,0.00001230902,0.000007088525,0.00003276351,0.00003499895,0.00001999955],"domain_scores_gemma":[0.9998798,0.00004106074,0.00003067709,0.00001428861,0.00001819375,0.00001588345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003148142,0.000009486826,0.0003047429,0.00001260482,0.000003748981,0.00007716911,0.00001047992,0.0000139863,0.9989656,0.00002826768,0.000030192,0.0005122448],"study_design_scores_gemma":[0.000003763605,0.0001164947,0.008045401,0.000004862401,0.000009985947,0.0006848677,0.00004210701,0.0006278867,0.9893287,0.00006957696,0.001059714,0.000006612329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871795,0.001418118,0.007961283,0.0002214634,0.00004969457,0.00002613495,0.0004248642,0.00009639425,0.002622513],"genre_scores_gemma":[0.9895397,0.0007496823,0.006047867,0.0002140098,0.00001556348,0.00003817722,0.0004336937,0.00001033961,0.002950947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356796,"threshold_uncertainty_score":0.004538953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598047668493268,"score_gpt":0.2668652242507141,"score_spread":0.2408847475657815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}