{"id":"W1966748010","doi":"10.1161/circresaha.109.216036","title":"Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells","year":2010,"lang":"en","type":"article","venue":"Circulation Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Nicotinamide adenine dinucleotide phosphate; Chemistry; Calmodulin; Angiotensin II; Nicotinamide adenine dinucleotide; Oxidase test; Mediator; Calcium; Cell biology; Biochemistry; Enzyme; Biology; NAD+ kinase; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002343603,0.0004199277,0.0005326966,0.0006699683,0.0008872393,0.0000972926,0.0004142737,0.000655386,0.001830777],"category_scores_gemma":[0.0002945398,0.0004170569,0.0001232965,0.000506193,0.0004805404,0.0003559075,0.0003476449,0.001699409,0.0004579278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613843,"about_ca_system_score_gemma":0.0001269289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009056698,"about_ca_topic_score_gemma":0.0002722054,"domain_scores_codex":[0.9956112,0.001018461,0.0008280338,0.001103999,0.0004132251,0.001025067],"domain_scores_gemma":[0.9979755,0.0004368471,0.0002528412,0.0006930787,0.0004693796,0.0001723918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003035708,0.0003142811,0.001437453,0.00001974954,0.00006557786,0.00004231711,0.0006758402,0.00002883445,0.9936526,0.000888744,0.0007194501,0.001851627],"study_design_scores_gemma":[0.003958,0.0002253778,0.01863855,0.00004464239,0.00002338535,0.00006156599,0.0001163249,0.0005379497,0.972936,0.001936221,0.001109769,0.0004122528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959032,0.0003782747,0.0005650064,0.0008270048,0.0005206484,0.001157035,0.0003521448,0.0001114257,0.0001852767],"genre_scores_gemma":[0.996349,0.00006059228,0.000128497,0.0001735759,0.0001305269,0.00007512174,0.0006257695,0.00008108389,0.00237579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0207166,"threshold_uncertainty_score":0.9998281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03076128315719584,"score_gpt":0.2907828817879454,"score_spread":0.2600215986307496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}