{"id":"W1966748010","doi":"10.1161/circresaha.109.216036","title":"Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells","year":2010,"lang":"en","type":"article","venue":"Circulation Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Nicotinamide adenine dinucleotide phosphate; Chemistry; Calmodulin; Angiotensin II; Nicotinamide adenine dinucleotide; Oxidase test; Mediator; Calcium; Cell biology; Biochemistry; Enzyme; Biology; NAD+ kinase; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264432,0.000127269,0.0001290801,0.00007428265,0.0001185195,0.0002168161,0.0001408314,0.0001420861,0.0005425848],"category_scores_gemma":[0.0001205649,0.00007025132,0.0001622092,0.00008656698,0.0001386763,0.000112629,0.0001184646,0.0001869098,0.0001132332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224353,"about_ca_system_score_gemma":0.0001370979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009183555,"about_ca_topic_score_gemma":0.0009122816,"domain_scores_codex":[0.999897,0.00002273028,0.000009846197,0.00002036259,0.00002904709,0.00002094814],"domain_scores_gemma":[0.9999591,0.000005472453,0.0000139718,0.000004364564,0.000006758937,0.00001026924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003186853,0.00006393296,0.001946064,0.00007368455,0.00001116873,0.0001186039,0.00004019784,0.00005738444,0.9945098,0.0001624205,0.00005860197,0.002639488],"study_design_scores_gemma":[0.00008400156,0.0008729434,0.09786582,0.00002123477,0.00007960248,0.0008303423,0.0001391413,0.003296764,0.8903637,0.0001847779,0.006251608,0.00001007114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938763,0.002923275,0.002097158,0.00009379269,0.00002157952,0.00001842066,0.0001143251,0.00002054113,0.0008346217],"genre_scores_gemma":[0.9962626,0.001283578,0.001276987,0.00004410999,0.000009902998,0.00002295137,0.0002048323,0.000002289386,0.0008928063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009183555,"threshold_uncertainty_score":0.001825988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03076128315719584,"score_gpt":0.2907828817879454,"score_spread":0.2600215986307496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}