{"id":"W1966765310","doi":"10.1074/jbc.m310848200","title":"The α2δ Auxiliary Subunit Reduces Affinity of ω-Conotoxins for Recombinant N-type (Cav2.2) Calcium Channels","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Conotoxin; Protein subunit; N-type calcium channel; Recombinant DNA; Chemistry; L-type calcium channel; Calcium channel; Calcium; Voltage-dependent calcium channel; Biochemistry; T-type calcium channel; Gene; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007865331,0.0002035832,0.0003697992,0.00001486545,0.000137029,0.0000188036,0.000575458,0.0003367349,0.00002002011],"category_scores_gemma":[0.001313782,0.0001215236,0.0003365238,0.0001059493,0.0002766521,0.000005338409,0.0001567637,0.0002939087,0.000001663453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000042481,"about_ca_system_score_gemma":0.0002592692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003779869,"about_ca_topic_score_gemma":0.000001201043,"domain_scores_codex":[0.9985515,0.0000569515,0.0006894455,0.0002346949,0.0001478707,0.0003195422],"domain_scores_gemma":[0.9983824,0.0001259152,0.0006471601,0.0002723584,0.0004376931,0.0001344526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006047518,0.0003164972,0.0005005446,0.00002373139,0.0001437118,0.000001275789,0.00002318365,0.00004987869,0.9962841,0.00001967876,0.001199792,0.0008328755],"study_design_scores_gemma":[0.001206219,0.00115052,0.0002071954,0.00003426336,0.00003294416,0.00008973492,0.0001894232,0.000002374894,0.979661,0.0004635384,0.01680634,0.0001563827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962989,0.001687853,0.0002117176,0.0006944334,0.0006156892,0.0001822968,0.00001720557,0.000006019281,0.0002858962],"genre_scores_gemma":[0.9970939,0.001106614,0.0006429043,0.00006506201,0.0007484169,0.000008053088,0.00002538489,0.00001532442,0.0002944036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01662302,"threshold_uncertainty_score":0.4955589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04084044352191967,"score_gpt":0.3048974857990124,"score_spread":0.2640570422770927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}