{"id":"W1966766732","doi":"10.1038/icb.2012.31","title":"Phosphatidylinositol‐3 kinase activity in B cells is negatively regulated by <i>Lyn</i> tyrosine kinase","year":2012,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Medical Research Council; Dunhill Medical Trust; Medical Research Council; National Health and Medical Research Council; State Government of Victoria; Menzies Foundation; Australian Government","keywords":"LYN; FYN; Phosphatidylinositol; Tyrosine kinase; Tyrosine-protein kinase CSK; Kinase; PI3K/AKT/mTOR pathway; Cell biology; Src family kinase; breakpoint cluster region; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Cancer research; Signal transduction; Biology; Molecular biology; Receptor; Biochemistry; SH2 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000682479,0.0001748502,0.000111329,0.0001620617,0.0001985089,0.0004588574,0.000114741,0.0001130179,0.0007626587],"category_scores_gemma":[0.0001212809,0.0001137559,0.0001155076,0.0001504847,0.0002182487,0.000132646,0.0001790727,0.0003552203,0.0004883938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708362,"about_ca_system_score_gemma":0.0002567358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141776,"about_ca_topic_score_gemma":0.001201791,"domain_scores_codex":[0.9999009,0.00001172201,0.000007371184,0.00001756282,0.00002900847,0.00003337444],"domain_scores_gemma":[0.9999367,0.000006939551,0.00001797938,0.00000701482,0.000009286696,0.00002208032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008113402,0.000005728427,0.0003800964,0.00001117502,0.000001325904,0.00003615388,0.000006693787,0.00002082196,0.9984646,0.00007633432,0.00003206134,0.0008838585],"study_design_scores_gemma":[0.00003644667,0.0001559078,0.04196585,0.00000953265,0.00002018029,0.0006595835,0.00005445017,0.0008558828,0.9516651,0.0002965775,0.004274674,0.000005833029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961015,0.001320691,0.0007348041,0.00008036198,0.000009583711,0.000004316197,0.0002157398,0.00004476133,0.001488185],"genre_scores_gemma":[0.9971809,0.0009542896,0.0004211061,0.00002597513,0.000007400894,0.000008665056,0.0003487595,0.00001141477,0.00104157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141776,"threshold_uncertainty_score":0.002690554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162203202728453,"score_gpt":0.2690422204912053,"score_spread":0.2574201884639208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}