{"id":"W1966766732","doi":"10.1038/icb.2012.31","title":"Phosphatidylinositol‐3 kinase activity in B cells is negatively regulated by <i>Lyn</i> tyrosine kinase","year":2012,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Medical Research Council; Dunhill Medical Trust; Medical Research Council; National Health and Medical Research Council; State Government of Victoria; Menzies Foundation; Australian Government","keywords":"LYN; FYN; Phosphatidylinositol; Tyrosine kinase; Tyrosine-protein kinase CSK; Kinase; PI3K/AKT/mTOR pathway; Cell biology; Src family kinase; breakpoint cluster region; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Cancer research; Signal transduction; Biology; Molecular biology; Receptor; Biochemistry; SH2 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003544935,0.000272705,0.000539845,0.0001494719,0.00009999379,0.000007987611,0.0001479803,0.0006331573,0.000315634],"category_scores_gemma":[0.00005759908,0.0002341527,0.00006666796,0.0002772288,0.0007641059,0.0001202059,0.000186589,0.0005667653,0.0001459729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00116445,"about_ca_system_score_gemma":0.0005877874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303911,"about_ca_topic_score_gemma":0.00001365515,"domain_scores_codex":[0.997968,0.000288607,0.0003064032,0.0004499766,0.00009155022,0.0008954168],"domain_scores_gemma":[0.9989369,0.000291528,0.0001145916,0.0004151857,0.0000609201,0.0001809078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001300044,0.0006185298,0.006929947,0.00006438481,0.00007971056,0.00004775403,0.0004376787,3.069328e-7,0.9800379,0.0001209835,0.003104381,0.00725839],"study_design_scores_gemma":[0.01191051,0.0005614497,0.008798835,0.00003312779,0.0000418762,0.00007951108,0.00008391331,0.0002054436,0.953269,0.00007180207,0.0247225,0.0002220356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787692,0.0174926,0.00002512186,0.0008616303,0.0003183998,0.0004163774,0.00003831165,0.00004647237,0.00203189],"genre_scores_gemma":[0.9945958,0.002034535,0.0001119198,0.0007892489,0.00007230212,0.00003745914,0.00006277193,0.00002522267,0.00227073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0267689,"threshold_uncertainty_score":0.9548469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162203202728453,"score_gpt":0.2690422204912053,"score_spread":0.2574201884639208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}