{"id":"W1966772968","doi":"10.1371/journal.pone.0109196","title":"A Mammalian Cell Based FACS-Panning Platform for the Selection of HIV-1 Envelopes for Vaccine Development","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; York University; École Polytechnique Fédérale de Lausanne; Bill and Melinda Gates Foundation","keywords":"Panning (audio); Biology; Virology; Transduction (biophysics); V3 loop; Monoclonal antibody; Population; Viral vector; Viral envelope; Computational biology; HEK 293 cells; Antibody; Gene; Molecular biology; Virus; Epitope; Genetics; Recombinant DNA; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005475106,0.000664435,0.000457862,0.0004919577,0.0003836853,0.0005037985,0.0004865846,0.0005025966,0.005574884],"category_scores_gemma":[0.0002900505,0.0003058635,0.0002853005,0.0003313611,0.0002081888,0.0003633236,0.0004425448,0.001124057,0.002531548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000279376,"about_ca_system_score_gemma":0.0002839167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003124716,"about_ca_topic_score_gemma":0.0007601214,"domain_scores_codex":[0.9995701,0.00009695649,0.00002983924,0.0001053341,0.0001529649,0.00004480716],"domain_scores_gemma":[0.9998865,0.00002752534,0.00001457886,0.00002224494,0.00002806869,0.00002113615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000040586,0.00002218136,0.00007940104,0.0000380272,0.000004197752,0.00002246499,0.00001906579,0.00008394495,0.9942933,0.000357425,0.0002896342,0.004749854],"study_design_scores_gemma":[0.00002743197,0.0002048064,0.0009806434,0.00001714458,0.00002406072,0.0004684415,0.00001810858,0.006405668,0.9657307,0.0004123819,0.02569159,0.00001901018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2014796,0.003875806,0.769276,0.0007672325,0.0003233288,0.001444647,0.004403741,0.004594275,0.01383538],"genre_scores_gemma":[0.3374271,0.003661066,0.6383448,0.0005111705,0.0001053204,0.001857645,0.006149918,0.0004587053,0.01148429],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005574884,"threshold_uncertainty_score":0.01864982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04193262167245616,"score_gpt":0.2409447179608432,"score_spread":0.1990120962883871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}