{"id":"W1966810565","doi":"10.1097/fpc.0b013e32830058aa","title":"Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice","year":2008,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Methylenetetrahydrofolate reductase; Methotrexate; Antifolate; Hyperhomocysteinemia; Chemistry; Dihydrofolate reductase; Homocysteine; Thymidylate synthase; Internal medicine; Endocrinology; Pharmacology; Antimetabolite; Biochemistry; Biology; Medicine; Chemotherapy; Fluorouracil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004093768,0.0008030977,0.0005671013,0.001202191,0.0003811157,0.0005790954,0.0005703788,0.001192565,0.002996825],"category_scores_gemma":[0.0002557208,0.000490188,0.0007191443,0.000460802,0.0006755244,0.0004285312,0.0002969209,0.001516816,0.001032266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007192488,"about_ca_system_score_gemma":0.0003458239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077443,"about_ca_topic_score_gemma":0.001470057,"domain_scores_codex":[0.9992993,0.0001197659,0.00009603916,0.0001997503,0.0001441371,0.0001409739],"domain_scores_gemma":[0.9993215,0.00007277341,0.0003197258,0.00007058642,0.00004328111,0.0001722184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006213323,0.0001504024,0.0006980376,0.00003648195,0.00001740543,0.0001227204,0.00003466181,0.00007712938,0.9969612,0.0001033907,0.00006083465,0.001116504],"study_design_scores_gemma":[0.0002838178,0.002794068,0.01732422,0.00004846968,0.0001787534,0.001354206,0.0001183511,0.001353118,0.9718704,0.0001658715,0.00447914,0.00002959218],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991546,0.001276531,0.002921861,0.0003052409,0.00005831866,0.00009702648,0.002112446,0.0003522611,0.001330358],"genre_scores_gemma":[0.984143,0.001670101,0.004421799,0.0002267728,0.00003698886,0.0002168357,0.001944589,0.0001554028,0.007184651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002996825,"threshold_uncertainty_score":0.01002538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05815727905958135,"score_gpt":0.3555951104776509,"score_spread":0.2974378314180695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}