{"id":"W1966817234","doi":"10.1139/bcb-2014-0038","title":"Conformational changes opening and closing the CFTR chloride channel: Insights from cysteine scanning mutagenesis","year":2014,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Chloride channel; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Gating; Cysteine; Chemistry; Biophysics; Mutagenesis; Biochemistry; Cell biology; Mutation; Biology; Genetics; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004038492,0.0006477204,0.0009123486,0.001355591,0.0002236459,0.0004967615,0.0006848929,0.0008403963,0.001117653],"category_scores_gemma":[0.0004513078,0.0002849278,0.0004293339,0.001237023,0.0004268202,0.0008420243,0.0004425394,0.001244321,0.001050897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005778452,"about_ca_system_score_gemma":0.0005236784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007972072,"about_ca_topic_score_gemma":0.001118985,"domain_scores_codex":[0.9998815,0.00001518624,0.00001432654,0.00002337745,0.0000531195,0.00001239344],"domain_scores_gemma":[0.9998686,0.00005244302,0.00001911762,0.000005522974,0.00003925329,0.00001506657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001031797,0.0001091957,0.0002905587,0.01581527,0.000114524,0.0005428775,0.0001135561,0.0009923526,0.02306193,0.008668262,0.02503652,0.9251518],"study_design_scores_gemma":[0.00002294398,0.0001598099,0.0009534475,0.001231291,0.00012305,0.001790545,0.00005140156,0.0002651917,0.007301421,0.002647629,0.985419,0.00003428281],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005060812,0.997543,0.0003807061,0.0002122823,0.0001536594,0.000004442358,0.00002054792,0.00001250814,0.001166897],"genre_scores_gemma":[0.001904852,0.9969218,0.0003795096,0.0001368132,0.00007002596,0.000005361297,0.00003407846,0.00000210939,0.0005454221],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001355591,"threshold_uncertainty_score":0.00419265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931713922630766,"score_gpt":0.3179353867350451,"score_spread":0.2886182475087374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}