{"id":"W1966834115","doi":"10.1016/j.chembiol.2013.04.007","title":"DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology","year":2013,"lang":"en","type":"review","venue":"Chemistry & Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":589,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto","funders":"National Human Genome Research Institute; Wake Forest University","keywords":"Biology; Limiting; Cancer chemotherapy; Serendipity; DNA damage; DNA; Cancer; Chemical biology; Computational biology; Drug discovery; Drug; Bioinformatics; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001685359,0.0006560496,0.001279349,0.00006149665,0.00004872408,0.00002759035,0.0005077656,0.001383486,0.0003573195],"category_scores_gemma":[0.00002633174,0.0005830288,0.0002741853,0.0001430804,0.0002761198,0.00000316749,0.0003764383,0.0004478139,0.00001145762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138524,"about_ca_system_score_gemma":0.0002812341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001055043,"about_ca_topic_score_gemma":0.0000124807,"domain_scores_codex":[0.997522,0.00009205104,0.0005585677,0.001122784,0.0000549632,0.0006496351],"domain_scores_gemma":[0.9988449,0.00002634799,0.0003114211,0.0005939728,0.0000523507,0.0001709699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001465301,0.00005789819,0.00008854353,0.001762796,0.000225092,0.000002502451,0.00001362171,6.508699e-8,0.2690744,0.00003370284,0.0002931368,0.7284336],"study_design_scores_gemma":[0.0005518243,0.00004763377,0.000004052041,0.0005136887,0.0001215961,0.00005032575,0.000007956831,0.000005018423,0.04007486,0.0002183815,0.9578041,0.0006004958],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01784169,0.9806444,0.00003272656,0.00007191985,0.0002815737,0.0004566525,0.0001993715,0.00002260939,0.000449059],"genre_scores_gemma":[0.002530873,0.9939852,0.0001165455,0.0003283329,0.0006709205,0.0004095376,0.001267025,0.00008881732,0.0006027013],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.957511,"threshold_uncertainty_score":0.9999129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05459283935742698,"score_gpt":0.3723953311055774,"score_spread":0.3178024917481505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}