{"id":"W1966834455","doi":"10.1593/neo.06568","title":"SAG/ROC-SCFβ-TrCP E3 Ubiquitin Ligase Promotes Pro-Caspase-3 Degradation as a Mechanism of Apoptosis Protection","year":2006,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Michigan Comprehensive Cancer Center; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; Hebrew University of Jerusalem; York University; University of Michigan","keywords":"Ubiquitin ligase; Cullin; Skp1; Biology; Molecular biology; Ubiquitin; Apoptosis; Cell biology; Caspase 3; F-box protein; Caspase; Caspase 8; Chemistry; Programmed cell death; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238755,0.0003501452,0.0002173226,0.0001721622,0.00008445425,0.0002256249,0.0001375595,0.0002079727,0.0009430787],"category_scores_gemma":[0.00007074261,0.0001018226,0.0002853517,0.0001217903,0.0001145898,0.0001796639,0.0001270112,0.0003628828,0.0003813842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000255239,"about_ca_system_score_gemma":0.0001233307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002495592,"about_ca_topic_score_gemma":0.0002401057,"domain_scores_codex":[0.9998728,0.00002050845,0.00001129205,0.00002487285,0.00003242621,0.00003800525],"domain_scores_gemma":[0.9999338,0.000006072552,0.00002195411,0.00000928095,0.0000112706,0.00001751653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009708982,0.00001854058,0.0001597611,0.00002663889,0.000006607392,0.0000517048,0.000005311569,0.00003017307,0.9986248,0.00007541099,0.0000337207,0.0008701557],"study_design_scores_gemma":[0.00001787622,0.0001709887,0.003758287,0.000003558834,0.00001137724,0.0004932221,0.00001094011,0.0008596456,0.9928769,0.000041163,0.001753142,0.00000283184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913862,0.00313219,0.003509518,0.00008432645,0.00002512202,0.00002475042,0.0002542815,0.0001625945,0.001421074],"genre_scores_gemma":[0.99612,0.0006638718,0.001202591,0.00002977018,0.000006436626,0.00001379839,0.0003752583,0.000007422479,0.001580868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009430787,"threshold_uncertainty_score":0.003154874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008501643725692017,"score_gpt":0.2161757613771163,"score_spread":0.2076741176514243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}