{"id":"W1966834455","doi":"10.1593/neo.06568","title":"SAG/ROC-SCFβ-TrCP E3 Ubiquitin Ligase Promotes Pro-Caspase-3 Degradation as a Mechanism of Apoptosis Protection","year":2006,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Michigan Comprehensive Cancer Center; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; Hebrew University of Jerusalem; York University; University of Michigan","keywords":"Ubiquitin ligase; Cullin; Skp1; Biology; Molecular biology; Ubiquitin; Apoptosis; Cell biology; Caspase 3; F-box protein; Caspase; Caspase 8; Chemistry; Programmed cell death; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001662555,0.0001961031,0.0001687467,0.00008852232,0.0001162584,0.00002862774,0.0001010976,0.0002742757,0.00004515608],"category_scores_gemma":[0.00004287506,0.0001848183,0.0001125932,0.0001544602,0.00003310238,0.00001069752,0.00005155224,0.0000848366,0.00001895681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002480954,"about_ca_system_score_gemma":0.00007936457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002664364,"about_ca_topic_score_gemma":0.0001052873,"domain_scores_codex":[0.9987979,0.00005601176,0.0003156166,0.0003839469,0.0002158696,0.0002306696],"domain_scores_gemma":[0.9993044,0.000006040249,0.0002136386,0.0002808995,0.0001391166,0.00005595681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000839678,0.0001354884,0.00006821899,0.00006210142,0.00002084003,0.000001319359,0.0000331947,0.00004669572,0.9869805,0.003481413,0.0001784409,0.008907839],"study_design_scores_gemma":[0.0005248241,0.0005247509,0.0005429703,0.00003907216,0.00003971628,0.00003769814,0.00004070721,0.000686648,0.9912795,0.003897479,0.00218922,0.0001973713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824698,0.000120517,0.015143,0.0001688806,0.0001535436,0.000802617,0.00001225097,0.00004031725,0.001089098],"genre_scores_gemma":[0.9948616,0.00003878068,0.002185493,0.00003321611,0.0002619661,0.0001299415,0.0003123999,0.00003422874,0.002142358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01295751,"threshold_uncertainty_score":0.7536671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008501643725692017,"score_gpt":0.2161757613771163,"score_spread":0.2076741176514243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}