{"id":"W1966845084","doi":"10.1016/j.abb.2004.08.024","title":"The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity","year":2004,"lang":"en","type":"review","venue":"Archives of Biochemistry and Biophysics","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"Cystathionine beta synthase; Cystathionine gamma-lyase; Transsulfuration; Cofactor; Enzyme; Biochemistry; Pyridoxal; Chemistry; Pyridoxal phosphate; Biosynthesis; Substrate (aquarium); Cysteine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416175,0.0002450307,0.0006221378,0.0000171929,0.00009505965,0.00001175548,0.0002283698,0.0001806879,2.40241e-7],"category_scores_gemma":[0.00004620161,0.000139939,0.0002816309,0.00005154231,0.001034588,0.000003376988,0.00007086914,0.0001116021,4.061714e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002220844,"about_ca_system_score_gemma":0.00020813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001629621,"about_ca_topic_score_gemma":0.000001847875,"domain_scores_codex":[0.9990118,0.00004793339,0.0004383106,0.0002698942,0.00006960164,0.0001624329],"domain_scores_gemma":[0.9986197,0.0003298194,0.0006064823,0.0003570188,0.00005199124,0.00003496916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002052767,0.00007774909,0.000002404304,0.007948459,0.0005244316,3.66794e-7,0.0000527502,0.00000165678,0.6973215,0.003840096,0.00001115901,0.2900141],"study_design_scores_gemma":[0.0008798418,0.0004394943,0.0000774862,0.002009926,0.001450584,0.00004575604,0.0007136707,0.00001501137,0.8620386,0.00270374,0.1292233,0.0004026803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01696525,0.9812068,0.0008345226,0.0000261145,0.00005794512,0.0003571268,0.0004495783,0.000002429203,0.0001002263],"genre_scores_gemma":[0.2295645,0.7700179,0.0001347042,0.000003171224,0.0001291336,0.00002267684,0.00007212549,0.00001275891,0.00004310743],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2896114,"threshold_uncertainty_score":0.5706547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297049032071741,"score_gpt":0.2582244141883519,"score_spread":0.2452539238676345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}