{"id":"W1966858164","doi":"10.1038/mtna.2013.48","title":"Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Small hairpin RNA; In vivo; Genetic enhancement; RNA interference; Viral vector; Integrase; Lentivirus; Virology; Biology; RNA; Medicine; Computational biology; Cancer research; Human immunodeficiency virus (HIV); Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006482728,0.0007733632,0.0004795465,0.0004784886,0.0002607691,0.0003583056,0.0004768492,0.0004882439,0.00157227],"category_scores_gemma":[0.0002858709,0.0002137966,0.0003615516,0.0001842253,0.0003676765,0.000311846,0.0001524126,0.00108009,0.0002851692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003538541,"about_ca_system_score_gemma":0.0004522016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007617046,"about_ca_topic_score_gemma":0.0007489663,"domain_scores_codex":[0.999736,0.00007402869,0.00001511553,0.0000530317,0.0000626996,0.00005913018],"domain_scores_gemma":[0.9996916,0.0000708471,0.00009100905,0.00003859634,0.00004298791,0.00006488115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009593789,0.002211657,0.0002356641,0.00007922198,0.00002203701,0.0000370509,0.00003463098,0.0008088012,0.9887971,0.0001381145,0.0001684373,0.006507828],"study_design_scores_gemma":[0.00017027,0.0237151,0.001222505,0.000009453403,0.00007404916,0.0001170739,0.00001267824,0.00166681,0.9717044,0.00005310498,0.001247288,0.000007332734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872649,0.001964711,0.007127601,0.0001482263,0.00007888625,0.0003171031,0.0005654921,0.0001737878,0.002359378],"genre_scores_gemma":[0.989729,0.001807834,0.00472614,0.00005719006,0.00004316397,0.0001937958,0.0007786165,0.00004076632,0.002623527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157227,"threshold_uncertainty_score":0.005259812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03226083350734438,"score_gpt":0.2955138434189087,"score_spread":0.2632530099115643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}