{"id":"W1966858164","doi":"10.1038/mtna.2013.48","title":"Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Small hairpin RNA; In vivo; Genetic enhancement; RNA interference; Viral vector; Integrase; Lentivirus; Virology; Biology; RNA; Medicine; Computational biology; Cancer research; Human immunodeficiency virus (HIV); Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006362781,0.0002047728,0.0002514445,0.0000604765,0.00003665039,0.00001223891,0.0004941563,0.0002254196,0.000193803],"category_scores_gemma":[0.00008319751,0.000150871,0.0002776518,0.0001641114,0.0001687769,0.000007276434,0.00007057464,0.0001221094,0.000009703647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002419001,"about_ca_system_score_gemma":0.0001758332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005365537,"about_ca_topic_score_gemma":0.00001528634,"domain_scores_codex":[0.9980892,0.0004355757,0.0005188494,0.0003516211,0.00038427,0.0002205077],"domain_scores_gemma":[0.9985943,0.00001829475,0.000225513,0.0007587846,0.0003565505,0.00004653328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002661038,0.0002907205,0.01010791,0.000005350632,0.00009113848,5.552002e-7,0.00008497955,0.002204181,0.9656726,0.000003849052,0.000122714,0.02114994],"study_design_scores_gemma":[0.003606362,0.0003421988,0.03003863,0.00003449206,0.00001308191,9.498959e-7,0.00003943644,0.005510784,0.9591818,0.00004804199,0.001016665,0.0001675899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948767,0.002080565,0.001575116,0.0002299092,0.0001079899,0.0008227244,0.00002596422,0.000006196271,0.0002748801],"genre_scores_gemma":[0.9972719,0.0006873094,0.0008002614,0.0009961367,0.0000335947,0.00008029164,0.00003561019,0.00003150849,0.00006337695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02098235,"threshold_uncertainty_score":0.6152342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03226083350734438,"score_gpt":0.2955138434189087,"score_spread":0.2632530099115643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}