{"id":"W1966862329","doi":"10.1016/j.bbagrm.2014.07.022","title":"The yeast Cyc8–Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene","year":2014,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"Nucleosome; SWI/SNF; Histone; Chromatin structure remodeling (RSC) complex; Biology; Chromatin; Chromatin immunoprecipitation; Histone H3; Acetylation; Cell biology; Gene; Genetics; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106905,0.0004793959,0.0002790542,0.0002616604,0.0001822362,0.000449008,0.0002656552,0.0002058992,0.0006375192],"category_scores_gemma":[0.0001634042,0.0003060904,0.0001926804,0.0001374323,0.0003338356,0.0001554945,0.0003543303,0.0004404311,0.0003124707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005638193,"about_ca_system_score_gemma":0.0002231273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001598133,"about_ca_topic_score_gemma":0.002614139,"domain_scores_codex":[0.9998543,0.00001081494,0.000009299967,0.00004264803,0.0000516308,0.00003126911],"domain_scores_gemma":[0.9998606,0.00001852649,0.00004008134,0.00002440841,0.00001174115,0.00004450457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003393946,0.000004223905,0.0001873321,0.000008874985,0.000002830152,0.00001837225,0.000005493508,0.0000669911,0.9992981,0.00002216336,0.000008889436,0.0003427224],"study_design_scores_gemma":[0.00001396735,0.00008473967,0.01004214,0.000003213796,0.00001050957,0.0001781087,0.00001438259,0.001523576,0.9871951,0.0000309075,0.000899111,0.000004221838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981021,0.0004863996,0.0009448861,0.00002714477,0.000004971144,0.000005229021,0.0001122917,0.00004727518,0.0002697477],"genre_scores_gemma":[0.9975861,0.0001545222,0.0008141644,0.00001469468,0.000003925236,0.00001319906,0.0005010371,0.00003258102,0.0008797278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598133,"threshold_uncertainty_score":0.004090786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215612177588887,"score_gpt":0.2417410124973753,"score_spread":0.2295848907214864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}