{"id":"W1966863570","doi":"10.1158/1535-7163.targ-09-b242","title":"Abstract B242: A phase I/II study of oncolytic reovirus plus chemotherapy (carboplatin/paclitaxel) in patients with advanced solid tumors (with emphasis on patients with squamous cell carcinoma of the head and neck (SCCHN)","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Oncolytic virus; Carboplatin; Neutropenia; Internal medicine; Chemotherapy; Paclitaxel; Oncology; Head and neck cancer; Cancer; Gastroenterology; Leukopenia; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001331091,0.002117293,0.002236049,0.0006388394,0.0006827745,0.001128936,0.001159299,0.001109394,0.003706742],"category_scores_gemma":[0.0005821843,0.0009460512,0.001194947,0.0006992422,0.001068584,0.0006761379,0.0003694103,0.003433844,0.001101846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009194341,"about_ca_system_score_gemma":0.00195126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001429419,"about_ca_topic_score_gemma":0.002421551,"domain_scores_codex":[0.999581,0.0001935003,0.00002071165,0.00007614163,0.00004455888,0.00008408112],"domain_scores_gemma":[0.9994774,0.00005374526,0.00007140162,0.00004309835,0.00003670684,0.0003177199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5088125,0.2485873,0.009237007,0.001410912,0.001528714,0.0007035989,0.0006584173,0.003288277,0.1376579,0.0003259682,0.004605245,0.08318418],"study_design_scores_gemma":[0.4004473,0.5801878,0.009112451,0.00003097139,0.0003780093,0.0003711125,0.00007356746,0.0007544171,0.005803451,0.0001040929,0.002706756,0.00003004915],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920266,0.001484468,0.0004932292,0.0003064923,0.0001218706,0.003522297,0.0008363912,0.00007177966,0.001136869],"genre_scores_gemma":[0.9835413,0.002595105,0.002210971,0.0006051119,0.0002447059,0.004806915,0.002488127,0.00004282798,0.003464833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003706742,"threshold_uncertainty_score":0.01240033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206950145137706,"score_gpt":0.2947909142369073,"score_spread":0.2827214127855303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}