{"id":"W1966863570","doi":"10.1158/1535-7163.targ-09-b242","title":"Abstract B242: A phase I/II study of oncolytic reovirus plus chemotherapy (carboplatin/paclitaxel) in patients with advanced solid tumors (with emphasis on patients with squamous cell carcinoma of the head and neck (SCCHN)","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Oncolytic virus; Carboplatin; Neutropenia; Internal medicine; Chemotherapy; Paclitaxel; Oncology; Head and neck cancer; Cancer; Gastroenterology; Leukopenia; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001194817,0.0004243114,0.0004870002,0.0001200357,0.0001064124,0.0000169128,0.0003670451,0.0001207274,0.000008529022],"category_scores_gemma":[0.00000609047,0.0002809039,0.00007038025,0.0004123785,0.0001779724,0.00001214478,0.00005241772,0.0002524478,1.889786e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001274266,"about_ca_system_score_gemma":0.0003308656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001275439,"about_ca_topic_score_gemma":0.0005659622,"domain_scores_codex":[0.9976786,0.0001275778,0.0004294244,0.0005910756,0.0007201568,0.0004531734],"domain_scores_gemma":[0.9983647,0.00001762191,0.0003709481,0.0008612226,0.0002841898,0.0001012791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1435629,0.02028843,0.3608046,0.0001544372,0.0005481238,0.00003629178,0.003756072,0.01117258,0.3632916,0.000002624154,0.000008326772,0.09637397],"study_design_scores_gemma":[0.04794827,0.1212125,0.3415022,0.0001217707,0.00008756956,7.596688e-7,0.0002225384,0.00005964387,0.4883443,0.000006073999,0.00005078663,0.0004436344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972299,0.0005838244,0.00001463521,0.00006461389,0.0000206305,0.001932008,0.00007064584,0.000007993604,0.00007578645],"genre_scores_gemma":[0.9990611,0.00003735988,0.00008108321,0.0005915216,0.00001423238,0.00009092529,0.00002571212,0.00008137336,0.00001669951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1250527,"threshold_uncertainty_score":0.9999643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206950145137706,"score_gpt":0.2947909142369073,"score_spread":0.2827214127855303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}