{"id":"W1966882041","doi":"10.1021/mp300668e","title":"Dose-Dependent Targeted Suppression of P-glycoprotein Expression and Function in Caco-2 Cells","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Caco-2; P-glycoprotein; Chemistry; Function (biology); Cell biology; Molecular biology; Cancer research; Pharmacology; In vitro; Biology; Biochemistry; Antibiotics; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351983,0.0001552491,0.0002442907,0.0001279913,0.00002906388,0.000009405726,0.00005789971,0.0001252043,0.0002910237],"category_scores_gemma":[0.000006264802,0.0001273718,0.00005511005,0.0001376055,0.00004250367,0.00007294984,0.0000315252,0.000228429,0.00001452438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002640782,"about_ca_system_score_gemma":0.0000330544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004183987,"about_ca_topic_score_gemma":0.000003015524,"domain_scores_codex":[0.9988723,0.0000498277,0.0002930107,0.0002390125,0.000318117,0.000227738],"domain_scores_gemma":[0.9994977,0.0000102506,0.00008023807,0.0001970989,0.00007128072,0.0001434663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002520369,0.0001680209,0.000848332,0.0002330037,0.00001765739,0.00008182246,0.0001384375,0.00006692585,0.9944075,0.00002185042,0.0000731606,0.003691252],"study_design_scores_gemma":[0.0027623,0.0001079685,0.003946715,0.0002097101,0.00007347766,0.000006272389,0.000115321,0.0008972559,0.9904422,0.0001803275,0.001132736,0.0001257766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933272,0.0013309,0.003562491,0.0001713889,0.0002197154,0.0008591686,0.000005457585,0.0000365304,0.0004871201],"genre_scores_gemma":[0.9974931,0.0001952038,0.001642885,0.0002075638,0.00002189875,0.00004117992,0.00002170873,0.00002979084,0.0003466451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004165896,"threshold_uncertainty_score":0.519407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241053754620559,"score_gpt":0.2649617689431876,"score_spread":0.252551231396982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}