{"id":"W1966882041","doi":"10.1021/mp300668e","title":"Dose-Dependent Targeted Suppression of P-glycoprotein Expression and Function in Caco-2 Cells","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Caco-2; P-glycoprotein; Chemistry; Function (biology); Cell biology; Molecular biology; Cancer research; Pharmacology; In vitro; Biology; Biochemistry; Antibiotics; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000442766,0.000449208,0.0007331751,0.0002507503,0.0002498023,0.0004692121,0.000337673,0.000520898,0.001283551],"category_scores_gemma":[0.0002669173,0.0002918658,0.0005265985,0.0005498808,0.000296466,0.000305995,0.0002321078,0.001306395,0.000717206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004847213,"about_ca_system_score_gemma":0.0003619858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001486133,"about_ca_topic_score_gemma":0.003130245,"domain_scores_codex":[0.9992803,0.0001238781,0.00009629726,0.0001271675,0.0002848343,0.00008758814],"domain_scores_gemma":[0.9997424,0.0000695837,0.00004502673,0.0000495839,0.00007052786,0.00002278901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003911829,0.00003901494,0.00003675531,0.00004406055,0.000004613525,0.00001765633,0.00002033836,0.00004702758,0.999138,0.00004846947,0.00007634007,0.0004886917],"study_design_scores_gemma":[0.00001273927,0.000254966,0.001327636,0.000003449847,0.00001646604,0.00007048217,0.00001888952,0.0009791221,0.9947584,0.00001690559,0.002535017,0.000005981626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638604,0.005163359,0.02027075,0.0006093149,0.0003309886,0.0003429159,0.002845968,0.0004847377,0.006091462],"genre_scores_gemma":[0.9401804,0.005042612,0.03377591,0.0004240221,0.0000605365,0.001027061,0.00467921,0.0001775055,0.01463271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486133,"threshold_uncertainty_score":0.004293919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241053754620559,"score_gpt":0.2649617689431876,"score_spread":0.252551231396982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}